Gene basic information

Cancerhepatic cancer,intrahepatic cholangiocarcinoma,


LncRNA CPS1-IT1 is down-regulated in hepatocellular carcinoma (1) and up-regulated in intrahepatic cholangiocarcinoma (2). It can affect cancer cell proliferation, migration and apoptosis (2, 1). Besides, it can inhibit EMT of hepatocellular carcinoma cells (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CPS1-IT1 others intrahepatic cholangiocarcinoma up onco + - - 26499888
1 CPS1-IT1 liver hepatic cancer down TS N-cadherin-,vimentin-,Snail-,Twist-,E-cadherin+,occludin+,Hsp90 - - - + 27248828



[1]. Wang TH, Yu CC, Lin YS, Chen TC, Yeh CT, et al. (2016). Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition. Oncotarget 7(28): 43588-43603. link pubmed
[2]. Ma SL, Li AJ, Hu ZY, Shang FS, Wu MC (2015). Co‑expression of the carbamoyl‑phosphate synthase 1 gene and its long non‑coding RNA correlates with poor prognosis of patients with intrahepatic cholangiocarcinoma. Mol Med Rep 12(6): 7915-26. link pubmed

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