|name||CTBP1 antisense RNA|
|alias_name||prostate cancer associated transcript 10|
LncRNA CTBP1-AS is an androgen-responsive long ncRNA, located in the antisense (AS) region of C-terminal binding protein 1 (CTBP1), which is a co-repressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally up-regulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumor growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumor-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||CTBP1-AS||prostate||prostate cancer||up||onco||CTBP1-,PSF+,p53-,SMAD3-,p21-||+||chemotherapy and hormone resistance||23644382|
Expression profile in human body map