CTBP1-AS

Gene basic information

symbol CTBP1-AS
name CTBP1 antisense RNA
location 4p16.3
alias_symbol PCAT10
alias_name prostate cancer associated transcript 10
Tissueprostate,
Cancerprostate cancer,


Description

LncRNA CTBP1-AS is an androgen-responsive long ncRNA, located in the antisense (AS) region of C-terminal binding protein 1 (CTBP1), which is a co-repressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally up-regulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumor growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumor-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CTBP1-AS prostate prostate cancer up onco CTBP1-,PSF+,p53-,SMAD3-,p21- + chemotherapy and hormone resistance 23644382

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.2 1.0 0.3 0.5 0.2 0.1 0.1 0.0 0.1 0.2 1.0 0.5 0.3 0.0 0.2 0.3 CTBP1-AS

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, et al. (2013). Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J 32(12): 1665-80. link pubmed



© Bioinformatics Group of XTBG