Gene basic information

symbol DACOR1
name DNMT1-associated colon cancer repressed lncRNA 1
location 15q22.33
alias_symbol TCONS_00023265
Cancercolorectal cancer,


LncRNA DACOR1 is down-regulated in colon cancer cells and DACOR1 induction appears to enhance DNA methylation at multiple loci without affecting DNMT1 protein level. Moreover, expression of DACOR1 leads to higher level of epithelial markers tight junction protein 1 (TJP1) protein, but not E-Cadherin. Besides, DACOR1 induction reduces the clonogenic potential of colon cancer cells (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DACOR1 colorectum colorectal cancer down TS DNMT1 TJP1+ - + epigenetic modification 26307088

External link


[1]. Merry CR, Forrest ME, Sabers JN, Beard L, Gao XH, et al. (2015). DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. Hum Mol Genet 24(21): 6240-53. link pubmed

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