DANCR

Gene basic information

symbol DANCR
name differentiation antagonizing non-protein coding RNA
location 4q12
alias_symbol ANCR|AGU2|lncRNA-ANCR
alias_name anti-differentiation ncRNA|adipogenesis up-regulated transcript 2|anti-differentiation noncoding RNA
Tissuecolorectum,liver,prostate,
Cancercolorectal cancer,hepatic cancer,prostate cancer,


Description

LncRNA DANCR is up-regulated in colorectal cancer (1), hepatic cancer (HCC) (2) and prostate cancer (3). Experiments show that DANCR markedly increases stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuates the stem-cell properties and in-vivo interference with DANCR action leads to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, DANCR relies largely on an association with CTNNB1 (2). Besides, DANCR promotes prostate cancer invasion and metastasis through repressing the expression of TIMP2/3 (3).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DANCR liver hepatic cancer up onco miR-214-,miR-320a-,miR-199a-,CTNNB1+ - cancer stem cells 25964079
1 DANCR colorectum colorectal cancer up / - 26617879
2 DANCR prostate prostate cancer up onco TIMP2/3- + hormonal resistance 27191265

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 25 30 fpkm 4.0 9.0 6.0 4.0 10.0 19.0 27.0 6.0 12.0 7.0 31.0 11.0 16.0 8.0 8.0 18.0 DANCR

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 10 20 30 40 50 fpkm DANCR type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Liu Y, Zhang M, Liang L, Li J, Chen YX (2015). Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. Int J Clin Exp Pathol 8(9): 11480-4. link pubmed
[2]. Yuan SX, Wang J, Yang F, Tao QF, Zhang J, et al. (2016). Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. Hepatology 63(2): 499-511. link pubmed
[3]. Jia J, Li F, Tang XS, Xu S, Gao Y, et al. (2016). Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3. Oncotarget 7(25): 37868-37881. link pubmed



© Bioinformatics Group of XTBG