DBH-AS1

Gene basic information

symbol DBH-AS1
name DBH antisense RNA 1
location 9q34.2
alias_symbol BPR
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA DBH-AS1 is up-regulated in hepatocellular carcinoma (HCC) and high DBH-AS1 levels are positively correlated with tumor size and HBsAg. DBH-AS1 promotes HCC cell proliferation and tumor growth. DBH-AS1 also induces cell-cycle progression in HCC cells. Overexpression of DBH-AS1 in HepG2 cells elevates the expression of oncogenic cell-cycle regulators including CDK6, CCND1, CCNE1, but reduces the expression of cyclin-dependent protein kinase inhibitors including p16, p21, p27. Moreover, DBH-AS1 inhibits serum starvation-induced apoptosis of HCC cells. At the molecular level, DBH-AS1 activates MAPK signaling pathways in HCC cells, meanwhile, DBH-AS1 is significantly induced by hepatitis B virus x protein (HBx) and inactivated by p53 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DBH-AS1 liver hepatic cancer up onco MAPK signaling CDK6+,CCND1+,CCNE1+,p16-,p21-,p27-,-p53,+HBX + 26393879

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 7 fpkm 0.0 2.0 0.2 0.0 0.0 0.1 0.8 0.1 7.0 0.3 2.0 1.0 0.2 0.0 2.0 0.2 DBH-AS1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Huang JL, Ren TY, Cao SW, Zheng SH, Hu XM, et al. (2015). HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma. Oncotarget 6(32): 33791-804. link pubmed



© Bioinformatics Group of XTBG