|name||DBH antisense RNA 1|
LncRNA DBH-AS1 is up-regulated in hepatocellular carcinoma (HCC) and high DBH-AS1 levels are positively correlated with tumor size and HBsAg. DBH-AS1 promotes HCC cell proliferation and tumor growth. DBH-AS1 also induces cell-cycle progression in HCC cells. Overexpression of DBH-AS1 in HepG2 cells elevates the expression of oncogenic cell-cycle regulators including CDK6, CCND1, CCNE1, but reduces the expression of cyclin-dependent protein kinase inhibitors including p16, p21, p27. Moreover, DBH-AS1 inhibits serum starvation-induced apoptosis of HCC cells. At the molecular level, DBH-AS1 activates MAPK signaling pathways in HCC cells, meanwhile, DBH-AS1 is significantly induced by hepatitis B virus x protein (HBx) and inactivated by p53 (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||DBH-AS1||liver||hepatic cancer||up||onco||MAPK signaling||CDK6+,CCND1+,CCNE1+,p16-,p21-,p27-,-p53,+HBX||+||26393879|
Expression profile in human body map