DILC

Gene basic information

symbol TFDP1
name transcription factor Dp-1
location 13q34
alias_symbol Dp-1|DRTF1|DP1|DILC
alias_name down-regulated in liver cancer stem cells
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA DILC is a non-coding transcript of protein coding gene DILC. It is down-regulated in liver cancer stem cells (LCSCs) and associated with poor prognosis. Lnc-DILC knockdown cells show elevated expression of LCSC markers and stemness-associated transcription factors, increased population of EpCAM+ or CD24+ cells and enhanced spheroid formation. In addition, lnc-DILC depletion facilitates hepatoma initiation and progression. These results indicate lnc-DILC could suppress LCSC expansion. Besides, lnc-DILC knockdown increases IL-6 autocrine signaling, and thus enhances the activation of IL-6/STAT3 pathway in LCSCs. Mechanically, lnc-DILC binds to IL-6 promoter and inhibits IL-6 transcription and can mediate the crosstalk between TNF-α/NF-κB signaling and autocrine IL-6/STAT3 cascade, thus regulating LCSC expansion in an inflammatory microenvironment (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DILC liver hepatic cancer down TS TNF-α/NF-κB,IL-6/STAT3 signaling IL-6 + cancer stem cells 26812074

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 fpkm 6.0 17.0 7.0 15.0 11.0 13.0 16.0 15.0 8.0 12.0 16.0 14.0 11.0 4.0 22.0 14.0 DILC

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Wang X, Sun W, Shen W, Xia M, Chen C, et al. (2016). Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis. J Hepatol 64(6): 1283-94. link pubmed



© Bioinformatics Group of XTBG