DQ786227

Gene basic information

SymbolDQ786227
Tissuelung,
Cancerlung cancer,


Description

The role of lncRNA DQ786227 in transformed human bronchial epithelial cells induced by benzo(a)pyrene is investigated. The transformed cell model is established using the BEAS-2B cell line, the study finds that DQ786227 is high and changed during the transformation of BEAS-2B cells. Silencing of DQ786227 expression in malignant transformed BEAS-2B cells leads to inhibition of cell proliferation and colony formation, and increased apoptosis. Moreover, DQ786227 dramatically promotes the ability of BEAS-2B-T cells to form colonies in vitro and develop tumors in nude mice (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DQ786227 lung lung cancer up onco + - chemical substances 24084393

Literature

[1]. Gao L, Mai A, Li X, Lai Y, Zheng J, et al. (2013). LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene. Toxicol Lett 223(2): 205-10. link pubmed



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