Gene basic information

Cancerlung cancer,


The role of lncRNA DQ786227 in transformed human bronchial epithelial cells induced by benzo(a)pyrene is investigated. The transformed cell model is established using the BEAS-2B cell line, the study finds that DQ786227 is high and changed during the transformation of BEAS-2B cells. Silencing of DQ786227 expression in malignant transformed BEAS-2B cells leads to inhibition of cell proliferation and colony formation, and increased apoptosis. Moreover, DQ786227 dramatically promotes the ability of BEAS-2B-T cells to form colonies in vitro and develop tumors in nude mice (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 DQ786227 lung lung cancer up onco + - chemical substances 24084393


[1]. Gao L, Mai A, Li X, Lai Y, Zheng J, et al. (2013). LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene. Toxicol Lett 223(2): 205-10. link pubmed

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