DQ786243

Gene basic information

Symbol

DQ786243

Tissue	colorectum,
Cancer	colorectal cancer,

Description

LncRNA DQ786243 is significantly up-regulated in the colorectal cancer (CRC) tissues. DQ786243 can promote CRC cell proliferation, migration and invasion, and inhibit apoptosis. Mechanistically, DQ786243 promotes cell proliferation via increasing the expression of Cyclin B1, CDC2 and p-CDC2, promotes EMT via suppressing E-cadherin expression but decreasing expression of Vimentin and N-cadherin, inhibits cell apoptosis via increasing the expression of the anti-apoptotic protein Bcl-2 but decreasing the expression of the pro-apoptotic proteins caspase-9 and caspase-3 and Bax (1).

Cancer related information

download as excel csv txt

	LncRNA	tissue	cancer type	expression level	oncogene/suppress gene	pathway	binding gene/factor	associated gene/factor	proliferation	apoptosis	migration	EMT	invasion	metastasis	prognosis	tag	PMID
0	DQ786243	colorectum	colorectal cancer	up	onco			Bcl-2+,caspase-9-,caspase-3-,Bax-,Cyclin B1+,CDC2+,p-CDC2+,E-cadherin-,vimentin+,N-cadherin+	+	-	+	+	+				26934980

Literature

[1]. Sun L, Xue H, Jiang C, Zhou H, Gu L, et al. (2016). LncRNA DQ786243 contributes to proliferation and metastasis of colorectal cancer both in vitro and in vivo. Biosci Rep 36(3). link pubmed