EBIC

Gene basic information

symbol TMPOP2
name thymopoietin pseudogene 2
location 16q23.1
alias_symbol lncRNA-EBIC
alias_name EZH2-binding lncRNA in cervical cancer
Tissuecervix,
Cancercervical cancer,


Description

LncRNA EBIC is up-regulated in cervical cancer (CC). EBIC silencing impairs CC cells migration and invasion. Moreover, EBIC can bind to EZH2. Furthermore, EBIC could inhibit E-cadherin by associating with EZH2, therefore EBIC might act as a facilitator in recruiting EZH2 to the promoter region of E-cadherin. EBIC and EZH2 may be two interdependent components of the H3K27me3 process (1)


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 EBIC cervix cervical cancer up onco EZH2 E-cadherin- + + 25007342

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 5.0 0.0 EBIC

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Sun NX, Ye C, Zhao Q, Zhang Q, Xu C, et al. (2014). Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS One 9(7): e100340. link pubmed



© Bioinformatics Group of XTBG