Gene basic information

Cancerbreast cancer,


LncRNA ENST00000515084 expression is predominantly cytoplasmic. The C allele of the rs12325489C>T polymorphism in the exonic regions of ENST00000515084 is associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrates that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of ENST00000515084 in vitro and in vivo, further affecting cell proliferation and tumor growth (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ENST00000515084 breast breast cancer / / miRNA-370 - SNP 24879036


[1]. Li N, Zhou P, Zheng J, Deng J, Wu H, et al. (2014). A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses. PLoS One 9(5): e98251. link pubmed

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