ENST00000515084

Gene basic information

SymbolENST00000515084
Tissuebreast,
Cancerbreast cancer,


Description

LncRNA ENST00000515084 expression is predominantly cytoplasmic. The C allele of the rs12325489C>T polymorphism in the exonic regions of ENST00000515084 is associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrates that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of ENST00000515084 in vitro and in vivo, further affecting cell proliferation and tumor growth (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ENST00000515084 breast breast cancer / / miRNA-370 - SNP 24879036

Literature

[1]. Li N, Zhou P, Zheng J, Deng J, Wu H, et al. (2014). A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses. PLoS One 9(5): e98251. link pubmed



© Bioinformatics Group of XTBG