EPB41L4A-AS2

Gene basic information

symbol EPB41L4A-AS2
name EPB41L4A antisense RNA 2 (head to head)
location 5q22.2
alias_symbol FLJ11235
alias_name
Tissuebreast,kidney,lung,
Cancerbreast cancer,lung cancer,renal cancer,


Description

LncRNA EPB41L4A-AS2 is down-regulated in breast, renal and lung cancer. Low expression is correlated with larger tumor size, higher stage and grade, ER and PR negative expression. Besides, low expression is correlated with poorer survival of the three kinds of cancers. In addition, a better overall survival is observed in TP53 wild-type breast cancer patients with high EPB41L4A-AS2 expression, while the converse is found for breast cancer patients with a TP53 mutation. Furthermore, overexpression of EPB41L4A-AS2 inhibits tumor cell proliferation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 EPB41L4A-AS2 breast breast cancer down TS p53 - + 26980733
1 EPB41L4A-AS2 lung lung cancer down TS - + 26980733
2 EPB41L4A-AS2 kidney renal cancer down TS - + 26980733

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm 2.0 1.0 0.3 1.0 0.2 0.4 0.8 0.1 0.2 0.3 0.3 0.4 0.3 0.2 0.4 3.0 EPB41L4A-AS2

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Xu S, Wang P, You Z, Meng H, Mu G, et al. (2016). The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. Oncotarget 7(15): 20704-17. link pubmed



© Bioinformatics Group of XTBG