FAL1

Gene basic information

symbol FALEC
name focally amplified long non-coding RNA in epithelial cancer
location 1q21.2
alias_symbol ncRNA-a1|FAL1
alias_name focally amplified lncRNA on chromosome 1
Tissueovary,thyroid,
Cancerovarian cancer,thyroid cancer,


Description

LncRNA FAL1, its copy number and expression are correlated with outcomes in ovarian cancer. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth (1).
Besides, FAL1 expression is increased in thyroid cancer (PTC) and high FAL1 expression increases the risk of multifocality (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 FAL1 ovary ovarian cancer / onco BMI1 p21- + mutation 25203321
1 FAL1 thyroid thyroid cancer up onco 26825907

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 fpkm 0.1 0.7 0.4 0.6 0.6 0.1 0.3 0.0 0.0 0.1 0.2 0.3 0.2 0.0 0.2 0.2 FAL1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 fpkm FAL1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, et al. (2014). A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 26(3): 344-57. link pubmed
[2]. Jeong S, Lee J, Kim D, Seol MY, Lee WK, et al. (2016). Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer. Medicine (Baltimore) 95(4): e2592. link pubmed



© Bioinformatics Group of XTBG