FENDRR

Gene basic information

symbol FENDRR
name FOXF1 adjacent non-coding developmental regulatory RNA
location 16q24.1
alias_symbol lincFOXF1|onco-lncRNA-21
alias_name
Tissuestomach,
Cancergastric cancer,


Description

LncRNA FENDRR expression is down-regulated in gastric cancer tissues and cell lines, and histone deacetylation is involved in the downregulation of FENDRR. Low FENDRR group shows greater invasion depth, higher tumor stage, more frequent lymphatic metastasis and shorter overall survival than the high FENDRR expression group. FENDRR exhibits an insignificant effect on gastric cancer cell proliferation, but represses gastric cancer cell migration, invasion and metastasis. Fibronectin1 is negatively regulated by FENDRR at both mRNA and protein levels. Inhibition of FENDRR contributes to the activation of MMP2/MMP9. These results demonstrate FENDRR acts as an oncogene in gastric cancer (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 FENDRR stomach gastric cancer down TS FN1-,MMP2-,MMP9- - - + 25167886

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 fpkm 0.0 0.4 0.2 0.0 10.0 0.0 0.1 0.0 0.1 9.0 0.6 0.1 23.0 0.0 0.1 0.3 FENDRR

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 2 4 6 8 10 12 14 fpkm FENDRR type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Xu TP, Huang MD, Xia R, Liu XX, Sun M, et al. (2014). Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression. J Hematol Oncol 7: 63. link pubmed



© Bioinformatics Group of XTBG