FEZF1-AS1

Gene basic information

symbol FEZF1-AS1
name FEZF1 antisense RNA 1
location 7q31.32
alias_symbol
alias_name
Tissuecolorectum,
Cancercolorectal cancer,


Description

LncRNA FEZF1-AS1 is up-regulated in human colorectal carcinoma (CRC) tissues. High-level expression of FEZF1-AS1 is significantly associated with T-stage, lymph node metastasis, distant metastasis and poor prognosis in patients with CRC. FEZF1-AS1 promotes CRC cell proliferation, migration and invasion. Knockdown of FEZF1-AS1 promotes G1 arrest, but does not cause apoptosis in CRC cells. In vitro, knockdown of FEZF1-AS1 inhibits tumor growth and metastasis. At the molecular level, knockdown of FEZF1-AS1 decreases the expression of FEZF1 mRNA and protein (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 FEZF1-AS1 colorectum colorectal cancer up onco FEZF1+ + + + - 26848625

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue −0.04 −0.02 0.00 0.02 0.04 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 FEZF1-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm FEZF1-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Chen N, Guo D, Xu Q, Yang M, Wang D, et al. (2016). Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma. Oncotarget 7(10): 11271-83. link pubmed



© Bioinformatics Group of XTBG