GClnc1

Gene basic information

SymbolGClnc1
Tissuestomach,
Cancergastric cancer,


Description

LncRNA GClnc1 is up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in gastric cancer. GClnc1 affects gastric cancer cell proliferation, invasiveness, and metastasis in multiple gastric cancer models. Mechanistically, GClnc1 binds WDR5 (a key component of histone methyltransferase complex) and KAT2A histone acetyltransferase, acting as a modular scaffold of WDR5 and KAT2A complexes to coordinate their localization and specify the histone modification pattern on the target genes, including SOD2, and consequently to alter gastric cancer cell biology (1).


Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 GClnc1 stomach gastric cancer up onco WDR5,KAT2A SOD2 + + + - 27147598

Literature

[1]. Sun TT, He J, Liang Q, Ren LL, Yan TT, et al. (2016). LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer Discov 6(7): 784-801. link pubmed



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