GHET1

Gene basic information

symbol GHET1
name gastric carcinoma proliferation enhancing transcript 1
location 7q36.1
alias_symbol lncRNA-GHET1
alias_name gastric carcinoma high expressed transcript 1
Tissuebladder,colorectum,stomach,
Cancerbladder cancer,colorectal cancer,gastric cancer,


Description

LncRNA GHET1 is up-regulated in bladder cancer (1), colorectal cancer (2) and gastric cancer (3). Increased GHET1 expression is correlated with advanced tumor status, grade and poor prognosis of bladder cancer and gastric cancer. Functionally, GHET1 promotes cell proliferation and invasion (1, 2, 3). Mechanistically, GHET1 negatively regulates p16 and p21, thus promoting cell proliferation. Moreover, GHET1 increases expression of vimentin, Snail, Slug, Twist, ZEB1 and fibronectin (mesenchymal marker) and decreases E-cadherin protein level (epithelial marker). As a consequence, EMT is promoted, and cancer cell invasiveness is increased (1, 2). In gastric cancer, GHET1 suppresses EGFR mRNA and protein level (4), GHET1 can also bind to IGF2BP1 protein and up-regulates c-Myc by increasing c-Myc mRNA stability (3).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 GHET1 stomach gastric cancer up onco IGF2BP1 c-Myc mRNA+ + + - 24397586
1 GHET1 bladder bladder cancer up onco p16-,p21-,vimentin+,fibronectin+,E-cadherin-,Snail+,Slug+,Twist+,ZEB1+ + + + - 25400817
2 GHET1 stomach gastric cancer up onco EGFR + + + hypoxia 26884908
3 GHET1 colorectum colorectal cancer up onco vimentin+,fibronectin+,E-cadherin- + + + 27131316
4 GHET1 colorectum colorectal cancer up onco + + + + 27931286

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 fpkm 0.3 0.7 0.8 0.5 0.2 0.3 0.7 0.1 0.2 0.2 0.6 0.8 0.3 0.0 0.7 0.2 GHET1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Li LJ, Zhu JL, Bao WS, Chen DK, Huang WW, et al. (2014). Long noncoding RNA GHET1 promotes the development of bladder cancer. Int J Clin Exp Pathol 7(10): 7196-205. link pubmed
[2]. Zhou J, Li X, Wu M, Lin C, Guo Y, et al. (2016). Knockdown of Long Noncoding RNA GHET1 Inhibits Cell Proliferation and Invasion of Colorectal Cancer. Oncol Res 23(6): 303-9. link pubmed
[3]. Yang F, Xue X, Zheng L, Bi J, Zhou Y, et al. (2014). Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J 281(3): 802-13. link pubmed
[4]. Yang Z, Wang R, Zhang T, Dong X (2015). Hypoxia/lncRNA-AK123072/EGFR pathway induced metastasis and invasion in gastric cancer. Int J Clin Exp Med 8(11): 19954-68. link pubmed



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