| Symbol | hDREH |
| Tissue | liver, |
| Cancer | hepatic cancer, |
LncRNA DREH is down-regulated by hepatitis B virus X protein (HBx) that is significantly down-regulated in the livers of HBx transgenic mice. Human ortholog RNA of Dreh (hDREH) is frequently down-regulated in HBV-related hepatocellular carcinoma (HCC) tissues in comparison with the adjacent noncancerous hepatic tissues, and its decrement significantly correlates with poor survival of HCC patients. Besides, DREH can reverse the high-migration phenotype of Hepa1-6 cells by affecting the protein vimentin (1).
| LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | hDREH | liver | hepatic cancer | down | / | vimentin+ | - | - | - | + | 23239537 |
[1]. Huang JF, Guo YJ, Zhao CX, Yuan SX, Wang Y, et al. (2013). Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology 57(5): 1882-92. link pubmed