LncRNA DREH is down-regulated by hepatitis B virus X protein (HBx) that is significantly down-regulated in the livers of HBx transgenic mice. Human ortholog RNA of Dreh (hDREH) is frequently down-regulated in HBV-related hepatocellular carcinoma (HCC) tissues in comparison with the adjacent noncancerous hepatic tissues, and its decrement significantly correlates with poor survival of HCC patients. Besides, DREH can reverse the high-migration phenotype of Hepa1-6 cells by affecting the protein vimentin (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
. Huang JF, Guo YJ, Zhao CX, Yuan SX, Wang Y, et al. (2013). Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology 57(5): 1882-92. link pubmed