HEIH

Gene basic information

symbol HEIH
name hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA
location 5q35.3
alias_symbol LINC-HEIH|lncRNA-HEIH|LINC00848|HCCAT2
alias_name long intergenic non-protein coding RNA 848|highly expressed in hepatocellular carcinoma long non-coding RNA|hepatocellular carcinoma associated transcript 2 (non-protein coding)
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA HEIH is up-regulated in hepatic carcinoma (HCC) and can be an independent prognostic factor for HCC patients. Functionally, HEIH can promote cell invasion (1). Moreover, HEIH is up regulated by SP1 and positively correlated with PCNA. Besides, HEIH associates with EZH2 and that this association is required for the expression of EZH2-regulated target genes (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HEIH liver hepatic cancer up onco EZH2,+SP1,PCNA- - 21769904
1 HEIH liver hepatic cancer up onco + 26550214

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 25 fpkm 20.0 22.0 10.0 10.0 16.0 5.0 13.0 25.0 5.0 19.0 25.0 17.0 17.0 5.0 14.0 24.0 HEIH

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang Y, Li Z, Zhang Y, Zhong Q, Chen Q, et al. (2015). Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells. Int J Clin Exp Med 8(8): 12956-62. link pubmed
[2]. Yang F, Zhang L, Huo XS, Yuan JH, Xu D, et al. (2011). Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 54(5): 1679-89. link pubmed



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