HNF1A-AS1

Gene basic information

symbol HNF1A-AS1
name HNF1A antisense RNA 1
location 12q24.31
alias_symbol FLJ38690
alias_name
Tissueesophagus,liver,lung,nasopharynx,stomach,
Canceresophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer,


Description

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues (1), nasopharyngeal carcinoma (2), oesophageal adenocarcinoma (3), hepatocellular carcinoma (4), and down-regulated in gastric cancer (5). HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter (1, 2, 5, 4). Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis (1, 2, 3). Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG (4). At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers (1, 2). In addition, HNF1A-AS1 can bind to DNA methyltransferase 1 (DNMT1) (1). Moreover, HNF1A-AS1 is positive correlated with H19 expression (3). Furthermore, HNF1A-AS1 is a sponge for miR-30b.


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HNF1A-AS1 esophagus esophageal squamous cell cancer up onco lncRNAH19+ + + + 24000294
1 HNF1A-AS1 esophagus esophageal squamous cell cancer up / 25608466
2 HNF1A-AS1 lung lung adenocarcinoma up onco DNMT1 cyclin D1+,E-cadherin-,N-cadherin+,β-catenin+ + + + - 25863539
3 HNF1A-AS1 stomach gastric cancer down / 26472090
4 HNF1A-AS1 nasopharynx nasopharyngeal cancer up onco CdC25C+,cyclin B1+,Snail+,Ncadherin+,vimentin+,E-cadherin- + + + + 26756620
5 HNF1A-AS1 liver hepatic cancer up onco miR-30b- Bcl-2+,ATG5+ + - 27084450

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 fpkm 0.2 0.9 0.3 0.3 2.0 0.1 4.0 0.2 0.7 0.3 0.1 0.6 0.2 0.1 0.4 0.3 HNF1A-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 fpkm HNF1A-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wu Y, Liu H, Shi X, Yao Y, Yang W, et al. (2015). The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. Oncotarget 6(11): 9160-72. link pubmed
[2]. Zhuang K, Wu Q, Jin CS, Yuan HJ, Cheng JZ (2016). Long non-coding RNA HNF1A-AS is upregulated and promotes cell proliferation and metastasis in nasopharyngeal carcinoma. Cancer Biomark 16(2): 291-300. link pubmed
[3]. Yang X, Song JH, Cheng Y, Wu W, Bhagat T, et al. (2014). Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut 63(6): 881-90. link pubmed
[4]. Liu Z, Wei X, Zhang A, Li C, Bai J, et al. (2016). Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p. Biochem Biophys Res Commun 473(4): 1268-75. link pubmed
[5]. Dang Y, Lan F, Ouyang X, Wang K, Lin Y, et al. (2015). Expression and clinical significance of long non-coding RNA HNF1A-AS1 in human gastric cancer. World J Surg Oncol 13: 302. link pubmed



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