Gene basic information

symbol CERNA2
name competing endogenous lncRNA 2 for microRNA let-7b
alias_symbol HOST2
alias_name human ovarian cancer specific transcript 2
Cancerepithelial ovarian cancer,


LncRNA HOST2 is up-regulated in epithelial ovarian cancer (EOC). Functionally, HOST2 promotes EOC cell migration, invasion and proliferation, while has no significant effect on the rate of cell apoptosis. HOST2 is a molecular sponge for let-7b and is repressed by let-7b. Moreover, HOST2 enhances the endogenous expression of metastasis-promoting genes that are targeted by let-7b (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HOST2 ovary epithelial ovarian cancer up onco -miR-let-7b + + + 25292198

External link


[1]. Gao Y, Meng H, Liu S, Hu J, Zhang Y, et al. (2015). LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. Hum Mol Genet 24(3): 841-52. link pubmed

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