HOTAIR

Gene basic information

symbol HOTAIR
name HOX transcript antisense RNA
location 12q13.13
alias_symbol HOXC-AS4|HOXC11-AS1|NCRNA00072
alias_name HOXC cluster antisense RNA 4 (non-protein coding)|non-protein coding RNA 72
Tissuebladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid,
Canceracute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer,


Description

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML) (1), glioma (2), laryngeal squamous cell carcinoma (3), oral squamous carcinoma (4), nasopharyngeal carcinoma (5), lung cancer (6), esophageal squamous cell carcinoma (7), gastric cancer (8), hepatocellular carcinoma (9), gallbladder cancer (10), pancreatic cancer (11), colorectal cancer (12), melanoma (13), osteosarcoma (14), bladder cancer (15), renal carcinoma (16), ovarian cancer (17), cervical cancer (18) and endometrial carcinoma (19). Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis (1, 18, 20, 12, 21, 19, 7, 10, 22, 2, 3, 5, 4, 17). Functionally, HOTAIR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT (1, 15, 23, 20, 24, 7, 22, 3, 14, 17). Further studies reveal that HOTAIR modulates physiological factors which participate in cell proliferation (2), apoptosis (25), autophagy (26), EMT (20, 23), migration, invasion (13) and angiogenesis (20, 27). Moreover, HOTAIR can bind to miRNAs and modulate their functions, thus affecting cancer progression (1, 10, 28, 29). Besides, HOTAIR also involves with Chemotherapy and hormone resistance (30, 31).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HOTAIR breast breast cancer up onco + + 20393566
1 HOTAIR liver hepatic cancer up onco + + chemotherapy resistance 21327457
2 HOTAIR colorectum colorectal cancer up onco + - 21862635
3 HOTAIR stomach gastrointestinal stromal tumors up onco PCHD10-,SEMA6A-,STK17B- + 22258453
4 HOTAIR liver hepatic cancer up onco MMP9+,VEGF+ 22289527
5 HOTAIR pancreas pancreatic cancer up onco - 22614017
6 HOTAIR breast breast cancer up / IGF mRNAs+ epigenetic modification 23124417
7 HOTAIR breast breast cancer up onco ER+,PR+ - 23133536
8 HOTAIR larynx laryngeal squamous cell cancer up onco PTEN methylation + - 23141928
9 HOTAIR nasopharynx nasopharyngeal cancer up onco + + - 23281836
10 HOTAIR liver hepatic cancer up / 23292722
11 HOTAIR others sarcoma up / MTDH+ 23543869
12 HOTAIR lung non-small-cell lung cancer up / Col-1+ 23668363
13 HOTAIR esophagus esophageal squamous cell cancer up onco + + - 23717443
14 HOTAIR esophagus esophageal squamous cell cancer up onco miR-1- + 27816685
15 HOTAIR lung non-small-cell lung cancer up onco + + - 23743197
16 HOTAIR stomach gastric cancer up onco vimentin+,N-cadherin+,E-cadherin-,ZO-1-,Snail+,Slug+,Twist+ + + - 23847441
17 HOTAIR others melanoma up onco MMP-2+,MMP-9+ + + 23862139
18 HOTAIR stomach gastric adenocarcinoma up / SUZ12+ 23888369
19 HOTAIR prostate prostate cancer up onco miR-34a + - + + hormonal resistance 23936419
20 HOTAIR esophagus esophageal squamous cell cancer up onco - 24022190
21 HOTAIR lung non-small-cell lung cancer up onco MMP2+,MMP9+,HOXA5- + + + + - 24103700
22 HOTAIR esophagus esophageal squamous cell cancer up onco Wnt/β-catenin WIF-1- + + - 24118380
23 HOTAIR stomach gastric cancer up onco + + - 24130837
24 HOTAIR esophagus esophageal squamous cell cancer up onco - + + - 24151120
25 HOTAIR lung lung adenocarcinoma up onco p21- chemotherapy resistance 24155936
26 HOTAIR nervous system glioma up onco cyclin D1+,cyclin E+,CDK4+,CDK2+,E2F1+,p21-,p16- + - 24203894
27 HOTAIR breast breast cancer up / - hormonal resistance 24258260
28 HOTAIR endometrium endometrial cancer up onco - 24285342
29 HOTAIR colorectum colorectal cancer / / - 24583926
30 HOTAIR lung small cell lung cancer up onco + + 24591352
31 HOTAIR kidney renal cancer up onco -miR-141- Snail+,ABL2+,ZEB1+ + - + 24616104
32 HOTAIR ovary ovarian cancer up onco MMP9+,MMP3+ + + + + - 24662839
33 HOTAIR liver hepatic cancer up onco RBM38- 24663081
34 HOTAIR cervix cervical cancer up onco - 24748337
35 HOTAIR endometrium endometrial cancer up onco + + 24758900
36 HOTAIR stomach gastric cancer up onco miR-331-3p,miR-124,AGO2 HER2- + + + - 24775712
37 HOTAIR esophagus esophageal squamous cell cancer / / SNP 24788237
38 HOTAIR colorectum colorectal cancer up onco E-cadherin-,vimentin+,MMP9+ + + + - 24840737
39 HOTAIR kidney renal cancer up / drug resistance 24935377
40 HOTAIR stomach gastric cancer up / 24949306
41 HOTAIR gallbladder gallbladder cancer up / +c-Myc,miRNA-130a- - 24953832
42 HOTAIR lung lung cancer up / MMP-2+,MMP-9+ + + + 25010625
43 HOTAIR bladder bladder cancer up onco WIF-1- + + 25030736
44 HOTAIR stomach gastric adenocarcinoma up onco + - + + 25063030
45 HOTAIR breast breast cancer / / MiR-7- 25070049
46 HOTAIR larynx laryngeal squamous cell cancer up / 25099764
47 HOTAIR kidney renal cancer up onco EZH2,H3K27me3 p53-,p21-,p16-,EZH2+ + + + 25149152
48 HOTAIR stomach gastric cancer up onco + + + - 25280565
49 HOTAIR breast breast cancer up / EZH2 P38+ + 25328122
50 HOTAIR cervix cervical cancer up onco - 25366139
51 HOTAIR cervix cervical cancer up / VEGF+,MMP-9+,β-catenin+,vimentin+,Snail+,Twist+,E-cadherin- + + + + - 25405331
52 HOTAIR nervous system glioma / / PRC2 chemotherapy resistance 25428914
53 HOTAIR colorectum colorectal cancer up onco + SNP 25432874
54 HOTAIR stomach gastric adenocarcinoma up / - SNP 25476857
55 HOTAIR cervix cervical cancer up onco p21- + - + + radiation resistance 25547435
56 HOTAIR breast breast cancer / / SNP 25586347
57 HOTAIR stomach gastric cancer up onco PCBP1- + + - 25612617
58 HOTAIR breast breast cancer up / pAkt- + - hormonal resistance 25613518
59 HOTAIR stomach gastric cancer / / SNP 25640751
60 HOTAIR bone osteosarcoma up onco MMP2+,MMP9+ + + + 25728753
61 HOTAIR breast breast cancer / / hormonal resistance 25739705
62 HOTAIR ovary ovarian cancer up onco E-cadherin-,vimentin+ + + cancer stem cells 25792974
63 HOTAIR ovary ovarian cancer up onco cyclin E+,Bcl-2+,caspase-9-,caspase-3-,BRCA1- + - - 25796453
64 HOTAIR nervous system glioma up / EZH2 NLK-,pRB-,cyclinD1+,N-cadherin+,Slug+,E-cadherin- + + - 25823657
65 HOTAIR ovary ovarian cancer up onco + + chemotherapy resistance 25824616
66 HOTAIR breast triple negative breast cancer / / β-catenin + chemotherapy resistance 25883211
67 HOTAIR others oral squamous cell cancer up onco EZH2 E-cadherin- + + 25901533
68 HOTAIR breast breast cancer up onco miR-148a + + hormonal resistance 25928008
69 HOTAIR bone marrow acute myelocytic leukemia up onco miR-193a c-KIT+ + - - 25979172
70 HOTAIR others phenotype of urothelial cancer up onco HOX family + 25994132
71 HOTAIR liver hepatic cancer up onco miR-218- 26024833
72 HOTAIR others oral squamous cell cancer up onco + - - 26036760
73 HOTAIR lung non-small-cell lung cancer up onco HIF-1α + + + hypoxia 26088446
74 HOTAIR nervous system glioma up / BRD4 + - 26111795
75 HOTAIR ovary ovarian cancer up onco miR-1,miR-214-3p,miR-330-5p MAPK1+ + + + 26117268
76 HOTAIR stomach gastric cancer up onco HGF/C-Met/Snail pathway PRC2 E-cadherin-,N-cadherin+,vimentin+,miR34a- + + + + 26136075
77 HOTAIR liver hepatic cancer up onco SETD2- cancer stem cells 26172293
78 HOTAIR nervous system glioma up onco miR-326 FGF1+ 26183397
79 HOTAIR stomach gastric cancer up / miR-152- 26187665
80 HOTAIR bone marrow acute myelocytic leukemia up onco + - 26261618
81 HOTAIR stomach gastric cancer up onco - chemotherapy resistance 26328013
82 HOTAIR ovary ovarian cancer up onco cyclin D1+,CDK4+,β-catenin+ + chemotherapy resistance 26341496
83 HOTAIR breast breast cancer up onco + hormonal resistance 26364613
84 HOTAIR prostate prostate cancer up onco + + hormonal resistance 26411689
85 HOTAIR bladder bladder cancer up onco EZH2+ - 26457124
86 HOTAIR bladder bladder cancer / / miR-205 26469956
87 HOTAIR ovary ovarian cancer up / - epigenetic regulation,chemotherapy resistance 26497652
88 HOTAIR cervix cervical cancer / onco mTOR/p70S6K- + - drug resistance 26523512
89 HOTAIR others head and neck squamous cell cancer / / Bcl-2,Bax,caspase-3,Cleaved caspase-3,Cytochrome c 26592246
90 HOTAIR others head and neck squamous cell cancer up onco HuR+ + + + 27941336
91 HOTAIR lung lung adenocarcinoma up onco FOXA1-,FOXA2-,LSH+ + + 26658322
92 HOTAIR colorectum colorectal cancer up onco p21- 26678886
93 HOTAIR lung small cell lung cancer / / DNMT1-,DNMT3b- - chemotherapy resistance,epigenetic modification 26707824
94 HOTAIR nasopharynx nasopharyngeal cancer up onco VEGFA+,Ang2+ + + - 26717040
95 HOTAIR lung lung cancer / / SNP,chemotherapy resistance 26729200
96 HOTAIR bladder bladder cancer up onco + + + chemotherapy resistance 26781446
97 HOTAIR bladder bladder cancer up / SNAI1+,Twist1+,ZEB1+,MMP1+,LAMB3+,LAMBC2+,ZO1- + + + 26800519
98 HOTAIR colorectum colorectal cancer / / biomarker 26823726
99 HOTAIR ovary ovarian cancer up onco miR-214-,miR-217- PIK3R3+ + + + 26826873
100 HOTAIR endometrium endometrial cancer / / - 26868332
101 HOTAIR stomach gastric cancer up / - 26935047
102 HOTAIR bone osteosarcoma up / SNP 26967389
103 HOTAIR pancreas pancreatic cancer up / 27028998
104 HOTAIR ovary ovarian cancer up onco NF-κB+ chemotherapy resistance 27041570
105 HOTAIR colorectum colorectal cancer / / E-cadherin- + cancer stem cells 27069543
106 HOTAIR bone marrow diffuse large B cell lymphoma up onco PI3K/AKT/NF-κB signaling pathway p-Akt+,p-NF-κB+ + - - 27122348
107 HOTAIR ovary epithelial ovarian cancer up / SNP 27166268
108 HOTAIR lung lung cancer / / miR-326- 27186394
109 HOTAIR nervous system glioma up onco EZH2,LSD1 CCND1+,CDK4+ + + cancer stem cells 27277755
110 HOTAIR colorectum colorectal cancer up / - 27298568
111 HOTAIR liver hepatic cancer up onco 27301338
112 HOTAIR cervix cervical cancer up onco NOTCH1+,HES1+,p300+,β-catenin+,N-cadherin+,vimentin+,Snail+,Twist+ + - + + + 27323817
113 HOTAIR breast breast cancer up / +FOXA1,+FOXM1 hormonal resistance 27378691
114 HOTAIR breast breast cancer / / Akt signaling IRF1 drug resistance 27388461
115 HOTAIR nervous system glioma / onco miR-148b-3p- + + 27446363
116 HOTAIR cervix cervical cancer up onco SNP 27467165
117 HOTAIR ovary ovarian cancer up onco miR‑373 Rab22a+ - + 27484896
118 HOTAIR thyroid papillary thyroid cancer / onco SNP 27549736
119 HOTAIR cervix cervical cancer up onco VEGF+,MMP-9+ + - 27574106
120 HOTAIR lung non-small-cell lung cancer up / KLF4 chemotherapy resistance 28066612

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.3 1.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.1 0.3 0.0 2.0 0.0 HOTAIR

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 fpkm HOTAIR type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Xing CY, Hu XQ, Xie FY, Yu ZJ, Li HY, et al. (2015). Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia. FEBS Lett 589(15): 1981-7. link pubmed
[2]. Zhang JX, Han L, Bao ZS, Wang YY, Chen LY, et al. (2013). HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol 15(12): 1595-603. link pubmed
[3]. Li D, Feng J, Wu T, Wang Y, Sun Y, et al. (2013). Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol 182(1): 64-70. link pubmed
[4]. Wu J, Xie H (2015). Expression of long noncoding RNA-HOX transcript antisense intergenic RNA in oral squamous cell carcinoma and effect on cell growth. Tumour Biol 36(11): 8573-8. link pubmed
[5]. Nie Y, Liu X, Qu S, Song E, Zou H, et al. (2013). Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci 104(4): 458-64. link pubmed
[6]. Wang R, Shi Y, Chen L, Jiang Y, Mao C, et al. (2015). The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH. Sci Rep 5: 17826. link pubmed
[7]. Lv XB, Lian GY, Wang HR, Song E, Yao H, et al. (2013). Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One 8(5): e63516. link pubmed
[8]. Hajjari M, Behmanesh M, Sadeghizadeh M, Zeinoddini M (2013). Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues. Med Oncol 30(3): 670. link pubmed
[9]. Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, et al. (2013). Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep 29(3): 946-50. link pubmed
[10]. Ma MZ, Li CX, Zhang Y, Weng MZ, Zhang MD, et al. (2014). Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer. Mol Cancer 13: 156. link pubmed
[11]. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, et al. (2013). HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32(13): 1616-25. link pubmed
[12]. Wu ZH, Wang XL, Tang HM, Jiang T, Chen J, et al. (2014). Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. Oncol Rep 32(1): 395-402. link pubmed
[13]. Tang L, Zhang W, Su B, Yu B (2013). Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. Biomed Res Int 2013: 251098. link pubmed
[14]. Wang B, Su Y, Yang Q, Lv D, Zhang W, et al. (2015). Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma. Mol Cells 38(5): 432-40. link pubmed
[15]. Yan TH, Lu SW, Huang YQ, Que GB, Chen JH, et al. (2014). Upregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer. Tumour Biol 35(10): 10249-57. link pubmed
[16]. Wu Y, Liu J, Zheng Y, You L, Kuang D, et al. (2014). Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells. Tumour Biol 35(12): 11887-94. link pubmed
[17]. Qiu JJ, Lin YY, Ye LC, Ding JX, Feng WW, et al. (2014). Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer. Gynecol Oncol 134(1): 121-8. link pubmed
[18]. Huang L, Liao LM, Liu AW, Wu JB, Cheng XL, et al. (2014). Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet 290(4): 717-23. link pubmed
[19]. He X, Bao W, Li X, Chen Z, Che Q, et al. (2014). The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. Int J Mol Med 33(2): 325-32. link pubmed
[20]. Kim HJ, Lee DW, Yim GW, Nam EJ, Kim S, et al. (2015). Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol 46(2): 521-30. link pubmed
[21]. Svoboda M, Slyskova J, Schneiderova M, Makovicky P, Bielik L, et al. (2014). HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis 35(7): 1510-5. link pubmed
[22]. Lee NK, Lee JH, Park CH, Yu D, Lee YC, et al. (2014). Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma. Biochem Biophys Res Commun 451(2): 171-8. link pubmed
[23]. Berrondo C, Flax J, Kucherov V, Siebert A, Osinski T, et al. (2016). Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes. PLoS One 11(1): e0147236. link pubmed
[24]. Lee M, Kim HJ, Kim SW, Park SA, Chun KH, et al. (2016). The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway. Oncotarget 7(28): 44558-44571. link pubmed
[25]. Qiu JJ, Wang Y, Ding JX, Jin HY, Yang G, et al. (2015). The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis. Exp Cell Res 333(2): 238-48. link pubmed
[26]. Dong L, Hui L (2016). HOTAIR Promotes Proliferation, Migration, and Invasion of Ovarian Cancer SKOV3 Cells Through Regulating PIK3R3. Med Sci Monit 22: 325-31. link pubmed
[27]. Fu WM, Lu YF, Hu BG, Liang WC, Zhu X, et al. (2016). Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways. Oncotarget 7(4): 4712-23. link pubmed
[28]. Ke J, Yao YL, Zheng J, Wang P, Liu YH, et al. (2015). Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. Oncotarget 6(26): 21934-49. link pubmed
[29]. Wang G, Li Z, Tian N, Han L, Fu Y, et al. (2016). miR-148b-3p inhibits malignant biological behaviors of human glioma cells induced by high HOTAIR expression. Oncol Lett 12(2): 879-886. link pubmed
[30]. Li J, Yang S, Su N, Wang Y, Yu J, et al. (2016). Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. Tumour Biol 37(2): 2057-65. link pubmed
[31]. Chiyomaru T, Yamamura S, Fukuhara S, Yoshino H, Kinoshita T, et al. (2013). Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One 8(8): e70372. link pubmed



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