HOTTIP

Gene basic information

symbol HOTTIP
name HOXA distal transcript antisense RNA
location 7p15.2
alias_symbol HOXA-AS6|RP1-170O19.3|HOXA13-AS1
alias_name HOXA cluster antisense RNA 6 (non-protein coding)|HOXA transcript at the distal tip|HOXA13 antisense RNA 1 (non-protein coding)
Tissuebone,colorectum,liver,lung,others,pancreas,prostate,stomach,
Cancercolorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer,


Description

HOTTIP is higher in tongue squamous cell carcinoma (1),non-small cell lung cancer (2), gastric cancer(3), hepatocellular carcinoma (4), colorectal cancer(CRC) (5), pancreatic cancer (6) and osteosarcoma (7). HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis (5, 3, 7, 1). HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (3, 4, 2, 7). Mechanistically, HOTTIP negatively regulates miR-125b (4) and HOXA13 (2), and positively regulates HOXA genes (4).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HOTTIP liver hepatic cancer up onco - 24114970
1 HOTTIP liver hepatic cancer up onco HOXA genes+,miR-125b- + + + 25424744
2 HOTTIP pancreas pancreatic cancer up onco + + + chemotherapy resistance 25889214
3 HOTTIP pancreas pancreatic cancer / onco PARP- + - + 25912306
4 HOTTIP others tongue squamous cell cancer up / - 26058875
5 HOTTIP lung lung cancer up onco Cdc25C+,Cyclin B1+,Cyclin D1+,Bcl-2+,Bcl-xL+ + - 26265284
6 HOTTIP bone osteosarcoma up onco + + + 26617868
7 HOTTIP colorectum colorectal cancer up / - 26617875
8 HOTTIP liver hepatic cancer up onco -miR-192,- miR-204 26710269
9 HOTTIP lung lung cancer / / SNP,chemotherapy resistance 26729200
10 HOTTIP prostate prostate cancer up onco Bcl-2+,Bax-,Cyclin D1+ + - 27064878
11 HOTTIP stomach gastric cancer up onco + - + + - 27103834
12 HOTTIP lung non-small-cell lung cancer up onco HOXA13- + - + 27347311
13 HOTTIP bone osteosarcoma up onco Wnt/β-catenin pathway + chemotherapy resistance 27347346

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 HOTTIP

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 fpkm HOTTIP type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang H, Zhao L, Wang YX, Xi M, Liu SL, et al. (2015). Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma. Tumour Biol 36(11): 8805-9. link pubmed
[2]. Sang Y, Zhou F, Wang D, Bi X, Liu X, et al. (2016). Up-regulation of long non-coding HOTTIP functions as an oncogene by regulating HOXA13 in non-small cell lung cancer. Am J Transl Res 8(5): 2022-32. link pubmed
[3]. Ye H, Liu K, Qian K (2016). Overexpression of long noncoding RNA HOTTIP promotes tumor invasion and predicts poor prognosis in gastric cancer. Onco Targets Ther 9: 2081-8. link pubmed
[4]. Tsang FH, Au SL, Wei L, Fan DN, Lee JM, et al. (2015). Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b. Liver Int 35(5): 1597-606. link pubmed
[5]. Ren YK, Xiao Y, Wan XB, Zhao YZ, Li J, et al. (2015). Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer. Int J Clin Exp Pathol 8(9): 11458-63. link pubmed
[6]. Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S (2015). The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget 6(13): 10840-52. link pubmed
[7]. Li F, Cao L, Hang D, Wang F, Wang Q (2015). Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma. Int J Clin Exp Pathol 8(9): 11414-20. link pubmed



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