| symbol | HOXA-AS2 |
| name | HOXA cluster antisense RNA 2 |
| location | 7p15.2 |
| alias_symbol | HOXA3as |
| alias_name |
| Tissue | bone marrow,stomach, |
| Cancer | gastric cancer,promyelocytic leukemia, |
LncRNA HOXA-AS2 is up-regulated in human gastric cancer (GC) tissues (1) and promyelocytic leukemia cells (2). In addition, HOXA-AS2 expression is induced by IFN-γ and TNF-α in neutrophils (2). Overexpression of HOXA-AS2 is associated with tumor size, TNM stage and poor prognosis of GC. HOXA-AS2 promotes cell proliferation and inhibits cell apoptosis (1, 2). HOXA-AS2 epigenetically silences P21, PLK3 and DDIT3 transcription by binding with EZH2 (1).
| LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | HOXA-AS2 | bone marrow | promyelocytic leukemia | up | onco | IFN-γ+,TNF-α+ | + | - | 23649634 | ||||||||
| 1 | HOXA-AS2 | stomach | gastric cancer | up | onco | EZH2 | p21-,PLK3-,DDIT3- | + | - | - | 26384350 |
Expression profile in human body map
Expression profile in TCGA
| entrez_id | 285943 |
| ucsc_id | uc064cfs.1 |
| Ensembl_gene_id | ENSG00000253552 |
| HGNC_id | HGNC:43745 |
| Omim_id | 616068 |
| cosmic | |
| lncrnadb | HOXA3as |
[1]. Xie M, Sun M, Zhu YN, Xia R, Liu YW, et al. (2015). Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression. Oncotarget 6(32): 33587-601. link pubmed
[2]. Zhao H, Zhang X, Frazão JB, Condino-Neto A, Newburger PE (2013). HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. J Cell Biochem 114(10): 2375-83. link pubmed