HOXA11-AS

Gene basic information

symbol HOXA11-AS
name HOXA11 antisense RNA
location 7p15.2
alias_symbol HOXA11-AS1|HOXA11S|HOXA-AS5|NCRNA00076
alias_name non-protein coding RNA 76|HOXA cluster antisense RNA 5 (non-protein coding)|HOXA11 antisense RNA 1 (non-protein coding)
Tissuenervous system,ovary,
Cancerepithelial ovarian cancer,glioma,


Description

HOXA11-AS acts as an oncogene in glioma (1) and tumor suppressor gene in epithelial ovarian cancer (2). HOXA11-AS can regulate cancer cell proliferation, migration, invasion and apoptosis (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 HOXA11-AS ovary epithelial ovarian cancer down TS - + - - SNP 26430965
1 HOXA11-AS nervous system glioma up onco + 26828136

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 fpkm 0.3 0.1 0.0 0.1 5.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 4.0 0.7 0.2 0.0 HOXA11-AS

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 5 10 15 20 fpkm HOXA11-AS type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wang Q, Zhang J, Liu Y, Zhang W, Zhou J, et al. (2016). A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma. Cancer Lett 373(2): 251-9. link pubmed
[2]. Richards EJ, Permuth-Wey J, Li Y, Chen YA, Coppola D, et al. (2015). A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. Oncotarget 6(33): 34745-57. link pubmed



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