Gene basic information

Cancerbreast cancer,


LncRNA JADE is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. JADE is up-regulated in human breast tumors. Knockdown of lncRNA-JADE significantly inhibits breast tumor growth. Mechanistically, JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. Consequently, lncRNA JADE induces histone H4 acetylation in the DDR (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 JADE breast breast cancer up onco H4 acetylation+,Jade1+, + - DNA damage 24097061


[1]. Su Y, Sun B, Lin X, Zhao X, Ji W, et al. (2016). Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma. Oncotarget 7(31): 49143-49155. link pubmed

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