JADE

Gene basic information

SymbolJADE
Tissuebreast,
Cancerbreast cancer,


Description

LncRNA JADE is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. JADE is up-regulated in human breast tumors. Knockdown of lncRNA-JADE significantly inhibits breast tumor growth. Mechanistically, JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. Consequently, lncRNA JADE induces histone H4 acetylation in the DDR (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 JADE breast breast cancer up onco H4 acetylation+,Jade1+, + - DNA damage 24097061

Literature

[1]. Su Y, Sun B, Lin X, Zhao X, Ji W, et al. (2016). Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma. Oncotarget 7(31): 49143-49155. link pubmed



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