Gene basic information

symbol NPTN-IT1
name NPTN intronic transcript 1
location 15q24.1
alias_symbol lncRNA-LET
alias_name long non-coding RNA, low expression in tumor
Cancercervical cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,nasopharyngeal cancer,


LncRNA LET is lower in nasopharyngeal carcinoma (1), esophageal squamous cell carcinoma (2), gallbladder cancer (3), gastric cancer (4), hepatic carcinoma,colorectal cancer,lung squamous cell cancer (5), and cervical cancer (6). LET expression level is associated with clinicopathological parameters such as pathological grade, clinical stage, lymph node metastasis, prognosis etc. (6, 3, 4). LET regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (2, 3). LET play biological functions via negatively regulating Bcl-2 (3) and positively regulates p53 (2), p21, caspase-3, Bax (3). Moreover, LET can regulate hypoxia signaling (5).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LET liver hepatic cancer down TS hypoxia signaling - hypoxia 23395002
1 LET gallbladder gallbladder cancer down TS p21+,caspase-3+,Bax+,Bcl-2- - + - + hypoxia 25213660
2 LET stomach gastric cancer down / + 25674261
3 LET cervix cervical cancer down TS + 25755778
4 LET nasopharynx nasopharyngeal cancer down TS -EZH2 epigenetic modification 26243049
5 LET esophagus esophageal squamous cell cancer down TS p53+ - + - - 26935396

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.6 1.0 2.0 1.0 0.4 2.0 0.5 0.2 0.1 0.9 1.0 0.8 1.0 0.4 0.7 0.5 LET

Expression profile in human body map

Genomic feature visualization


External link


[1]. Sun Q, Liu H, Li L, Zhang S, Liu K, et al. (2015). Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell. Med Oncol 32(9): 226. link pubmed
[2]. Wang PL, Liu B, Xia Y, Pan CF, Ma T, et al. (2016). Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression. Mol Med Rep 13(4): 3074-82. link pubmed
[3]. Ma MZ, Kong X, Weng MZ, Zhang MD, Qin YY, et al. (2015). Long non-coding RNA-LET is a positive prognostic factor and exhibits tumor-suppressive activity in gallbladder cancer. Mol Carcinog 54(11): 1397-406. link pubmed
[4]. Zhou B, Jing XY, Wu JQ, Xi HF, Lu GJ (2014). Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer. Int J Clin Exp Pathol 7(12): 8893-8. link pubmed
[5]. Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, et al. (2013). Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell 49(6): 1083-96. link pubmed
[6]. Jiang S, Wang HL, Yang J (2015). Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer. Int J Clin Exp Pathol 8(1): 806-11. link pubmed

© Bioinformatics Group of XTBG