LINC00052

Gene basic information

symbol LINC00052
name long intergenic non-protein coding RNA 52
location 15q25.3
alias_symbol FLJ31461
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LINC00052 is down-regulated in hepatocellular carcinoma. It can inhibit cell invasion, migration and proliferation. NTRK3 is the target gene of LINC00052. Down-expression of NTRK3 could increase cell invasion, migration and proliferation. Meanwhile, LINC00052 could regulate NTRK3 expression by forming complementary base-pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00052 liver hepatic cancer down TS miR-128,miR-485-3p p-Erk1/2-,NTRK3-,AGBL1 - - - 27351280

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.02 0.04 0.06 0.08 0.10 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 LINC00052

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm LINC00052 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Xiong D, Sheng Y, Ding S, Chen J, Tan X, et al. (2016). LINC00052 regulates the expression of NTRK3 by miR-128 and miR-485-3p to strengthen HCC cells invasion and migration. Oncotarget 7(30): 47593-47608. link pubmed



© Bioinformatics Group of XTBG