LINC00184

Gene basic information

symbol LINC00184
name long intergenic non-protein coding RNA 184
location 1q42.3
alias_symbol HANC
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA LINC00184 is highly expressed in human hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). In addition, LINC00184 is required for self-renewal of liver CSCs and tumor propagation in mice. Moreover, LINC00184 associates with β-catenin and the methyltransferase EZH2, thereby promoting β-catenin methylation. Methylation suppresses the ubiquitination of β-catenin and promotes its stability, thus leading to activation of Wnt-β-catenin signaling. Accordingly, the expression of LINC00184, EZH2 and Wnt-β-catenin targets are positively correlated with cancer severity and prognosis of people with HCC (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00184 liver hepatic cancer up onco Wnt-β-catenin signaling β-catenin,EZH2,Wnt-β-catenin cancer stem cells 27239797

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 fpkm 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 LINC00184

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.01 0.02 0.03 0.04 0.05 0.06 0.07 0.08 fpkm LINC00184 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhu P, Wang Y, Huang G, Ye B, Liu B, et al. (2016). lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol 23(7): 631-9. link pubmed



© Bioinformatics Group of XTBG