LINC00467

Gene basic information

symbol LINC00467
name long intergenic non-protein coding RNA 467
location 1q32.3
alias_symbol MGC14801
alias_name
Tissuenervous system,
Cancerneuroblastoma,


Description

N-Myc suppresses LINC00467 gene expression through directly binding to the LINC00467 gene promoter and reducing LINC00467 promoter activity. Moreover, LINC00467 reduces RD3 mRNA expression. Besides, Affymetrix microarray analysis reveals that one of genes significantly up-regulated by LINC00467 siRNA is the tumor suppressor gene DKK1. Importantly, knocking-down LINC00467 expression with siRNA in neuroblastoma cells reduces the number of viable cells and increases the percentage of apoptotic cells, while co-transfection with DKK1 siRNA would block the effects (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00467 nervous system neuroblastoma / onco -N-Myc RD3-,DKK1+ + - 24586304

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 25 30 35 40 fpkm 1.0 2.0 1.0 2.0 0.4 1.0 2.0 0.7 2.0 1.0 1.0 1.0 1.0 0.5 39.0 3.0 LINC00467

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 2 4 6 8 fpkm LINC00467 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Atmadibrata B, Liu PY, Sokolowski N, Zhang L, Wong M, et al. (2014). The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc. PLoS One 9(2): e88112. link pubmed



© Bioinformatics Group of XTBG