LINC00473

Gene basic information

symbol LINC00473
name long intergenic non-protein coding RNA 473
location 6q27
alias_symbol bA142J11.1
alias_name
Tissuelung,
Cancernon-small-cell lung cancer,


Description

LINC00473 is consistently the most highly induced gene in LKB1-inactivated human primary non-small cell lung cancer (NSCLC) samples and derived cell lines. Elevated LINC00473 expression correlates with poor prognosis, and the sustained LINC00473 expression is required for the growth and survival of LKB1-inactivated NSCLC cells. Mechanistically, LINC00473 is induced by LKB1 inactivation and subsequent cyclic AMP-responsive element-binding protein (CREB)/CREB-regulated transcription coactivator (CRTC) activation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00473 lung non-small-cell lung cancer up onco cAMP/CREB +LKB1 + - 27140397

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 10 12 fpkm 0.1 0.0 0.1 0.0 0.3 0.1 0.4 0.0 0.4 0.0 0.2 12.0 0.4 0.0 0.3 0.1 LINC00473

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 fpkm LINC00473 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Chen Z, Li JL, Lin S, Cao C, Gimbrone NT, et al. (2016). cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth. J Clin Invest 126(6): 2267-79. link pubmed



© Bioinformatics Group of XTBG