LINC00617

Gene basic information

symbol TUNAR
name TCL1 upstream neural differentiation-associated RNA
location 14q32.2
alias_symbol TUNA|HI-LNC78
alias_name Tcl1 upstream neuron-associated lincRNA|Human Islet Long Non Coding RNA 78
Tissuebreast,
Cancerbreast cancer,


Description

Linc00617 is up-regulated in breast cancer tissues and associated tumor grade, lymph node metastasis and overall survival. Linc00617 promotes motility and invasion of breast cancer cells. Linc00617 can also influence EMT via affecting epithelial marker E-cadherin, N-cadherin and vimentin. Besides, ectopic expression of linc00617 can increase the binding of hnRNP-K at the promoter region of stemness factor Sox2 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00617 breast breast cancer up onco hnRNP-K Sox2+,E-cadherin-,N-cadherin+,vimentin+ + + + 26207516

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 fpkm 0.0 0.0 4.0 0.1 0.1 0.0 0.3 0.1 0.0 0.1 0.0 0.2 0.4 0.0 1.0 0.0 LINC00617

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm LINC00617 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Li H, Zhu L, Xu L, Qin K, Liu C, et al. (2017). Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer. Mol Carcinog 56(1): 3-17. link pubmed



© Bioinformatics Group of XTBG