LINC00974

Gene basic information

symbol LINC00974
name long intergenic non-protein coding RNA 974
location 17q21.2
alias_symbol
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LINC00974 is up-regulated with positively correlation with KRT19 (an lncRNA beyond the Flank10kb class with protein) in hepatic carcinoma (HCC). Both LINC00974 and KRT19 expression are significantly correlated with decreased tumor differentiation grade, increased tumor size, and metastasis. LINC00974 promotes cell proliferation and invasion. Besides, LINC00974 induces an inhibition of tumor growth and metastasis. Mechanistically, LINC00974 affects KRT19 expression by acting as a competing endogenous RNA (ceRNA) to interact with miR-642. In addition, NOTCH and TGF-β signal pathways are promoted by the upregulation of KRT19 induced by LINC00974 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC00974 liver hepatic cancer up onco Notch and TGF-β+ MiR-642 KRT19+ + + 25476897

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.02 0.04 0.06 0.08 0.10 fpkm 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 LINC00974

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.02 0.04 0.06 0.08 0.10 0.12 0.14 0.16 fpkm LINC00974 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Tang J, Zhuo H, Zhang X, Jiang R, Ji J, et al. (2014). A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. Cell Death Dis 5: e1549. link pubmed



© Bioinformatics Group of XTBG