|name||long intergenic non-protein coding RNA 1133|
|Cancer||colorectal cancer,lung squamous cell cancer,non-small-cell lung cancer,|
LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples (1).
While in lung cancer, LINC01133 is up-regulated and associated with poor prognosis of lung cancer patients (2,). It can promote lung cancer cell lines migration, invasion and inhibit apoptosis (2, 3). Furthermore, LINC01133 suppresses KLF2, P21 and E-cadherin transcription by interacting with EZH2 and LSD1 (3).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||LINC01133||lung||lung squamous cell cancer||up||onco||+||+||-||25908174|
|1||LINC01133||lung||non-small-cell lung cancer||up||onco||EZH2,LSD1||KLF2-,p21-,E-cadherin-||+||-||+||+||+||-||26840083|
Expression profile in human body map
Expression profile in TCGA
. Kong J, Sun W, Li C, Wan L, Wang S, et al. (2016). Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. Cancer Lett 380(2): 476-84. link pubmed
. Zhang J, Zhu N, Chen X (2015). A novel long noncoding RNA LINC01133 is upregulated in lung squamous cell cancer and predicts survival. Tumour Biol 36(10): 7465-71. link pubmed
. Zang C, Nie FQ, Wang Q, Sun M, Li W, et al. (2016). Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer. Oncotarget 7(10): 11696-707. link pubmed