LINC01133

Gene basic information

symbol LINC01133
name long intergenic non-protein coding RNA 1133
location 1q23.2
alias_symbol
alias_name
Tissuecolorectum,lung,
Cancercolorectal cancer,lung squamous cell cancer,non-small-cell lung cancer,


Description

LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples (1).
While in lung cancer, LINC01133 is up-regulated and associated with poor prognosis of lung cancer patients (2,). It can promote lung cancer cell lines migration, invasion and inhibit apoptosis (2, 3). Furthermore, LINC01133 suppresses KLF2, P21 and E-cadherin transcription by interacting with EZH2 and LSD1 (3).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC01133 lung lung squamous cell cancer up onco + + - 25908174
1 LINC01133 lung non-small-cell lung cancer up onco EZH2,LSD1 KLF2-,p21-,E-cadherin- + - + + + - 26840083
2 LINC01133 colorectum colorectal cancer down TS SRSF6 E-cadherin+,vimentin-,-TGF-β - - + 27443606

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 7 8 fpkm 2.0 1.0 0.6 6.0 8.0 0.3 0.9 0.4 0.1 1.0 1.0 4.0 3.0 0.1 4.0 0.9 LINC01133

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 5 10 15 20 25 30 fpkm LINC01133 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Kong J, Sun W, Li C, Wan L, Wang S, et al. (2016). Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. Cancer Lett 380(2): 476-84. link pubmed
[2]. Zhang J, Zhu N, Chen X (2015). A novel long noncoding RNA LINC01133 is upregulated in lung squamous cell cancer and predicts survival. Tumour Biol 36(10): 7465-71. link pubmed
[3]. Zang C, Nie FQ, Wang Q, Sun M, Li W, et al. (2016). Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer. Oncotarget 7(10): 11696-707. link pubmed



© Bioinformatics Group of XTBG