LINC01225

Gene basic information

symbol LINC01225
name LINC01225 pseudogene
location 1p35.2
alias_symbol
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LINC01225 is up-regulated in hepatocellular carcinoma (HCC). High LINC01225 expression is significantly associated with tumor size, tumor differentiation grade, tumor capsular integrity, tumor TNM stage, metastasis and prognosis. LINC01225 promotes proliferation and invasion of HCC cells. Mechanism study finds LINC01225 can promote HCC growth and invasion via EGFR/MAPK pathway. More specifically, that LINC01225 could bind to EGFR, thereby increasing the protein level of EGFR (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LINC01225 liver hepatic cancer up onco EGFR/MAPK pathway EGFR mRNA EGFR protein level+ + + + - 26938303

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.000 0.025 0.050 0.075 0.100 0.125 0.150 0.175 0.200 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 LINC01225

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Wang X, Zhang W, Tang J, Huang R, Li J, et al. (2016). LINC01225 promotes occurrence and metastasis of hepatocellular carcinoma in an epidermal growth factor receptor-dependent pathway. Cell Death Dis 7: e2130. link pubmed



© Bioinformatics Group of XTBG