linc223

Gene basic information

Symbollinc223
Tissuebone marrow,
Canceracute myelocytic leukemia,


Description

Linc-223, the host transcript of miR-223, is down-regulated in acute myelocytic leukemia (AML) and its expression is associated with myeloid differentiation. It has two splicing variants, named linc-223-1 and linc-223-2. Through qPCR, linc-223 is significantly induced during monocytic differentiation. Linc-223 can stimulate differentiation of AML cells, while diminishing their proliferation rate. Linc-223 might act as a competing endogenous RNA (ceRNA) for miR-125-5p. There exists a specific crosstalk between linc-223 and IRF4 mRNA through competition for miR-125-5p binding (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 linc223 bone marrow acute myelocytic leukemia down TS miR-125-5p IRF4 differentiation 27517498

Literature

[1]. Mangiavacchi A, Sorci M, Masciarelli S, Larivera S, Legnini I, et al. (2016). The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA. Oncotarget 7(37): 60155-60168. link pubmed



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