Linc-223, the host transcript of miR-223, is down-regulated in acute myelocytic leukemia (AML) and its expression is associated with myeloid differentiation. It has two splicing variants, named linc-223-1 and linc-223-2. Through qPCR, linc-223 is significantly induced during monocytic differentiation. Linc-223 can stimulate differentiation of AML cells, while diminishing their proliferation rate. Linc-223 might act as a competing endogenous RNA (ceRNA) for miR-125-5p. There exists a specific crosstalk between linc-223 and IRF4 mRNA through competition for miR-125-5p binding (1).