Gene basic information

Cancerhepatic cancer,


LncRNA URHC expression is increased in hepatocellular carcinoma (HCC) tissues and cells, its higher expression is correlated with poor overall survival. Functionally, URHC promotes cell proliferation and inhibits apoptosis. At molecular level, the study finds the ZAK gene, which is located near URHC on the same chromosome, is negatively correlated with URHC. Then, they confirm that URHC promotes HCC growth through ZAK via the ERK/MAPK signaling pathway (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 lnc-URHC liver hepatic cancer up onco ERK/MAPK ZAK- + - - 25013376


[1]. Xu WH, Zhang JB, Dang Z, Li X, Zhou T, et al. (2014). Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma. Int J Biol Sci 10(7): 664-76. link pubmed

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