LncRNA URHC expression is increased in hepatocellular carcinoma (HCC) tissues and cells, its higher expression is correlated with poor overall survival. Functionally, URHC promotes cell proliferation and inhibits apoptosis. At molecular level, the study finds the ZAK gene, which is located near URHC on the same chromosome, is negatively correlated with URHC. Then, they confirm that URHC promotes HCC growth through ZAK via the ERK/MAPK signaling pathway (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|