LOC389641

Gene basic information

SymbolLOC389641
Tissuepancreas,
Cancerpancreatic ductal adenocarcinoma,


Description

LncRNA LOC389641 is increased in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines. LOC389641 is significantly associated with TNM stage and lymph node metastasis and also an independent factor for the prognosis of PDAC individual. LOC389641 increases proliferation, migration and invasion, but inhibits apoptosis of PDAC cells. LOC389641 is positively correlated with Ki67, thus promotes cell proliferation. Moreover, LOC389641 increases tumor invasion by regulating EMT-related epithelial marker E-cadherin and the mesenchymal markers vimentin and snail. The study also finds that TNFRSF10A might be a connection between LOC389641 and E-cadherin (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LOC389641 pancreas pancreatic ductal adenocarcinoma up onco Ki67+,TNFRSF10A+,E-cadherin-,vimentin+,Snail+ + - + + + - 26708505

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.2 1.0 0.1 0.4 0.2 0.0 0.3 0.7 0.2 0.6 2.0 0.1 0.2 0.0 0.1 0.1 LOC389641

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 fpkm LOC389641 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

Literature

[1]. Zheng S, Chen H, Wang Y, Gao W, Fu Z, et al. (2016). Long non-coding RNA LOC389641 promotes progression of pancreatic ductal adenocarcinoma and increases cell invasion by regulating E-cadherin in a TNFRSF10A-related manner. Cancer Lett 371(2): 354-65. link pubmed



© Bioinformatics Group of XTBG