|Cancer||pancreatic ductal adenocarcinoma,|
LncRNA LOC389641 is increased in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines. LOC389641 is significantly associated with TNM stage and lymph node metastasis and also an independent factor for the prognosis of PDAC individual. LOC389641 increases proliferation, migration and invasion, but inhibits apoptosis of PDAC cells. LOC389641 is positively correlated with Ki67, thus promotes cell proliferation. Moreover, LOC389641 increases tumor invasion by regulating EMT-related epithelial marker E-cadherin and the mesenchymal markers vimentin and snail. The study also finds that TNFRSF10A might be a connection between LOC389641 and E-cadherin (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||LOC389641||pancreas||pancreatic ductal adenocarcinoma||up||onco||Ki67+,TNFRSF10A+,E-cadherin-,vimentin+,Snail+||+||-||+||+||+||-||26708505|
Expression profile in human body map
Expression profile in TCGA