LOC400891

Gene basic information

SymbolLOC400891
Tissueprostate,
Cancerprostate cancer,


Description

LOC400891 is higher in prostate cancer (PCa) tissues and cells. The patients with higher LOC400891 expression have advanced clinical features and a shorter biochemical recurrence-free survival time. Furthermore, multivariate analysis shows that the status of LOC400891 expression is an independent predictor of biochemical recurrence-free survival in PCa. Functionally, knockdown of LOC400891 could inhibit cell proliferation, migration and invasion. Mechanistically, LOC400891 is involved in the promotion of PCa cell proliferation and seems to be mediated by modulation of the PI3K-AKT-mTOR pathway and PTEN gene. LOC400891 involves cell migration and invasion by regulating the epithelial–mesenchymal transition (EMT) pathway (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LOC400891 prostate prostate cancer up onco PI3K-AKT-mTOR p-PTEN-,vimentin+,β-catenin+,Twist+,Snail+ + + + - 26797783

Literature

[1]. Wang J, Cheng G, Li X, Pan Y, Qin C, et al. (2016). Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer. Tumour Biol 37(7): 9603-13. link pubmed



© Bioinformatics Group of XTBG