LOC572558

Gene basic information

symbol PGM5-AS1
name PGM5 antisense RNA 1
location 9q21.11
alias_symbol FAM233A
alias_name family with sequence similarity 233, member A
Tissuebladder,
Cancerbladder cancer,


Description

LOC572558 expression is markedly decreased in bladder cancer tissues and bladder cancer cell lines. Moreover, ectopic expression of LOC572558 inhibits cell proliferation and motility, induces S phase arrest of the cell cycle and promotes cell apoptosis in bladder cancer cell lines. Further studies verify that overexpression of LOC572558 is associated with dephosphorylation of AKT, MDM2 and phosphorylation of p53 protein (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LOC572558 bladder bladder cancer down TS p53 signaling pathway pAKT-,MDM2-,p-p53+ - - 27130667

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 50 100 150 200 250 300 350 400 fpkm 3.0 2.0 0.1 2.0 73.0 0.2 0.7 0.0 0.3 0.3 0.9 0.9 384.0 0.4 24.0 0.6 LOC572558

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 10 20 30 40 50 60 fpkm LOC572558 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhu Y, Dai B, Zhang H, Shi G, Shen Y, et al. (2016). Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis. Cancer Lett 380(2): 369-74. link pubmed



© Bioinformatics Group of XTBG