| symbol | PCAT18 |
| name | prostate cancer associated transcript 18 (non-protein coding) |
| location | 18q11.2 |
| alias_symbol | LINC01092 |
| alias_name | long intergenic non-protein coding RNA 1092 |
| Tissue | prostate, |
| Cancer | prostate cancer, |
LOC728606 is up-regulated in prostate cancer (PCa). LOC728606 is detectable in plasma samples and increases incrementally from healthy individuals to those with localized and metastatic PCa. The study identifies a LOC728606-associated expression signature (PES), which is highly PCa-specific and activated in metastatic vs. primary PCa samples. The PES is significantly associated with androgen receptor (AR) signaling. Accordingly, AR activation dramatically up-regulates LOC728606 expression in vitro and in vivo. LOC728606 silencing significantly inhibits PCa cell proliferation and triggers caspase 3/7 activation, with no effect on non-neoplastic cells. LOC728606 silencing also inhibits PCa cell migration and invasion (1).
| LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | LOC728606 | prostate | prostate cancer | up | onco | androgen receptor (AR) signalling | caspase-3-,caspase 7- | + | - | + | + | hormonal resistance | 24519926 |
Expression profile in human body map
Expression profile in TCGA
| entrez_id | 728606 |
| ucsc_id | |
| Ensembl_gene_id | ENSG00000265369 |
| HGNC_id | HGNC:49211 |
| Omim_id | |
| cosmic | |
| lncrnadb |