LUADT1

Gene basic information

symbol LUADT1
name lung adenocarcinoma associated transcript 1
location 6q24.3
alias_symbol
alias_name
Tissuelung,
Cancerlung adenocarcinoma,


Description

LncRNA LUADT1 is up-regulated in lung adenocarcinoma (LUAD), and correlated with the tumor stage, but not with N stage or TNM stage. LUADT1 promotes cell proliferation via regulating cyclin D1, cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6) and Ki67. In addition, LUADT1 binds to SUZ12 and epigenetically inhibits p27 expression by mediating H3K27 trimethylation at the promoter region of p27 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LUADT1 lung lung adenocarcinoma up onco SUZ12 P27-,cyclin D1+,CDK4+,CDK6+,Ki67+ + 26291312

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 fpkm 0.1 0.4 0.4 0.1 0.1 0.2 0.2 0.0 0.3 0.3 0.0 0.2 0.2 0.0 0.2 0.1 LUADT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0000 0.0025 0.0050 0.0075 0.0100 0.0125 0.0150 0.0175 0.0200 fpkm LUADT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Qiu M, Xu Y, Wang J, Zhang E, Sun M, et al. (2015). A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27. Cell Death Dis 6: e1858. link pubmed



© Bioinformatics Group of XTBG