LUCAT1

Gene basic information

symbol LUCAT1
name lung cancer associated transcript 1 (non-protein coding)
location 5q14.3
alias_symbol SCAL1
alias_name smoke and cancer associated lncRNA 1
Tissuelung,
Cancerlung cancer,non-small-cell lung cancer,


Description

LncRNA LUCAT1 can be induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines. It is located in chromosome 5 with four exons and three introns. The expression of LUCAT1 is regulated transcriptionally by nuclear factor erythroid 2-related factor (NRF2). A nuclear factor erythroid-derived 2 (NF-E2) motif is identified in the promoter region that shows binding to NRF2 after its activation. Functionally, the siRNA knockdown of LUCAT1 in human bronchial epithelial cells shows a significant potentiation of cytotoxicity induced by CSE in vitro (1).
Another study focusing on LUCAT1 reveals it is obviously up-regulated in non-small cell lung cancer tissues and its expression is associated with tumor size, tumor TNM stage, lymphatic metastasis and overall survival. LUCAT1 can significantly promote proliferation of lung cancer cells. Furthermore, LUCAT1 plays a crucial role in G1 arrest. What's more, LUCAT1 is correlated with the enhancer of zeste homolog 2 (EZH2) by repressing the expression of p21 and p57 (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 LUCAT1 lung lung cancer up / -NRF2 chemical substances 23672216
1 LUCAT1 lung non-small-cell lung cancer up onco EZH2 p21-,P57- + - 27198302

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.0 0.1 0.1 0.1 0.0 0.3 0.0 2.0 0.0 0.9 0.3 0.1 0.0 0.3 0.0 1.0 LUCAT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 1.0 1.2 fpkm LUCAT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Thai P, Statt S, Chen CH, Liang E, Campbell C, et al. (2013). Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol 49(2): 204-11. link pubmed
[2]. Renhua G, Yue S, Shidai J, Jing F, Xiyi L (2016). 165P: Long noncoding RNA LUCAT1 is associated with poor prognosis in human non-small cell lung cancer and affects cell proliferation via regulating p21 and p57 expression. J Thorac Oncol 11(4 Suppl): S129. link pubmed



© Bioinformatics Group of XTBG