MALAT1

Gene basic information

symbol MALAT1
name metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
location 11q13.1
alias_symbol PRO1073|MALAT-1|NCRNA00047|HCN|NEAT2|LINC00047|mascRNA
alias_name metastasis associated in lung adenocarcinoma transcript 1|non-protein coding RNA 47|hepcarcin|nuclear enriched abundant transcript 2|nuclear paraspeckle assembly transcript 2 (non-protein coding)|long intergenic non-protein coding RNA 47
Tissuebladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,
Cancerbladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer,


Description

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma (1),tongue cancer (2), oral squamous cell carcinoma (3), esophageal cancer (4), lung cancer (5, 6), breast cancer (7), gastric cancer (8), hepatic carcinoma (9), multiple myeloma (10), gallbladder cancer (11), osteosarcoma (12), pancreatic cancer (13), colorectal cancer (14), prostate cancer (15), bladder cancer (16), renal cell carcinoma (17), cervical cancer (18) and ovarian cancer (19). MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis (18, 4, 1, 5, 13, 17). Functionally, MALAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT (16, 20, 18, 21, 2, 22). At molecular level, MALAT1 can bind plenty of miRNAs (23, 7, 24, 25, 26). Moreover, it can modulate factors involving with cell proliferation (21), apoptosis (2), autophagy (22), invasion (3, 3), EMT (26, 5) and angiogenesis (3). Besides, it participates in hormonotherapy, radiotherapy and chemotherapy for resistance (27, 28, 29).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 MALAT1 lung non-small cell lung cancer up onco + - 12970751
1 MALAT1 nervous system neuroblastoma up / CREB 20149803
2 MALAT1 cervix cervical cancer up onco caspase-3-,caspase-8-,Bax-,Bcl-2+,Bcl-xL+ + + 20213048
3 MALAT1 lung lung cancer / / motility related gene + 20937273
4 MALAT1 lung non-small-cell lung cancer up onco + + - 22088988
5 MALAT1 bladder bladder cancer up onco + - + 23153939
6 MALAT1 lung lung cancer up / metastasis-associated genes,-ASOs + 23243023
7 MALAT1 prostate prostate cancer up onco + + + chemotherapy resistance 23845456
8 MALAT1 prostate prostate cancer up onco + + + hormonal resistance 23845456
9 MALAT1 colorectum colorectal cancer up onco Wnt/β-catenin signaling β-catenin+ + + - chemotherapy resistance 24244343
10 MALAT1 bladder bladder cancer up onco suz12 E-cadherin-,+TGF-β + - 24449823
11 MALAT1 liver hepatic cancer up / -SRSF1 +YAP 24468535
12 MALAT1 liver hepatic cancer up onco mTOR pathway SRSF1+ 27993818
13 MALAT1 bladder bladder cancer up / hsa-miR-125b- 24512851
14 MALAT1 breast breast cancer / / + + + hormonal resistance 24525122
15 MALAT1 gallbladder gallbladder cancer up onco ERK/MAPK MMP-9+ + + 24658096
16 MALAT1 nervous system neuroblastoma / onco +JMJD1A +N-Myc + + 24742640
17 MALAT1 pancreas pancreatic cancer up / - 24815433
18 MALAT1 pancreas pancreatic cancer up -miR-216a 28034748
19 MALAT1 stomach gastric cancer up onco SF2/ASF + 24857172
20 MALAT1 cervix cervical cancer up / HPV16 E6/E7+ + + HPV 24932303
21 MALAT1 colorectum colorectal cancer up onco SFPQ + + 25025966
22 MALAT1 colorectum colorectal cancer up / - 25031737
23 MALAT1 lung non-small-cell lung cancer up / Bcl-2 25036876
24 MALAT1 endometrium endometrial cancer / / -PCDH10 25085246
25 MALAT1 bone marrow multiple myeloma up / Sp1 and LTBP3 promoter,GF-β1 cancer stem cells 25187517
26 MALAT1 lung lung cancer up onco + + + 25217850
27 MALAT1 pancreas pancreatic cancer up onco + + + + cancer stem cells 25269958
28 MALAT1 bone marrow multiple myeloma up / - 25369863
29 MALAT1 bone osteosarcoma up onco PI3K/AKT PCNA+,pPI3Kp85α+,Akt+ + + + 25431257
30 MALAT1 colorectum colorectal cancer up onco AKAP-9+ + + + + 25446987
31 MALAT1 kidney renal clear cell cancer up onco + + + - 25480417
32 MALAT1 pancreas pancreatic cancer up onco - 25481511
33 MALAT1 esophagus esophageal squamous cell cancer / / miR-101,miR-217 25538231
34 MALAT1 colorectum colorectal cancer up onco CCL5,Snail+ + + chemotherapy resistance 25546229
35 MALAT1 bone osteosarcoma up / miR-9 + + + + - hormonal resistance 25592968
36 MALAT1 kidney renal cancer up onco miR-205-,c-Fos+,Ezh2+ - + + - 25600645
37 MALAT1 nervous system glioma up / - 25613066
38 MALAT1 esophagus esophageal squamous cell cancer up onco ATM-CHK2 pathway pATM-,pCHK2-,pCDC25C-,pCDK1- + - + + 25613496
39 MALAT1 stomach gastric cancer up onco MEK/extracellular signal + + - 25721209
40 MALAT1 nervous system glioma / / WNT pathway WIF1 - 25772239
41 MALAT1 pancreas pancreatic cancer / onco Sox2 cancer stem cells,chemotherapy resistance 25811929
42 MALAT1 cervix cervical cancer up onco miRNA-124 GRB2 + - + HPV 26242259
43 MALAT1 lung non-small-cell lung cancer up onco TDP-43+ + + + 26265046
44 MALAT1 breast breast cancer up / miR-1- 26275461
45 MALAT1 cervix cervical cancer up onco miR-145 + - radiation resistance 26311052
46 MALAT1 liver hepatic cancer up onco +Sp1 +Sp3 26352013
47 MALAT1 cervix cervical cancer up onco + - + - 26400521
48 MALAT1 esophagus middle thoracic esophageal cancer up / - radiation resistance 26406400
49 MALAT1 kidney renal clear cell cancer up onco -miR-200s ZEB2+ + + 26461224
50 MALAT1 nasopharynx nasopharyngeal cancer up onco miR-1 Slug+ - radiation resistance,cancer stem cells 26482776
51 MALAT1 esophagus esophageal squamous cell cancer up onco + - + + - 26493997
52 MALAT1 prostate prostate cancer up / EZH2 chemotherapy resistance 26516927
53 MALAT1 others oral squamous cell cancer up onco β-catenin and NF-κB signaling MMP-2+,MMP-9+,VEGF+,TIMP-3- + + + - 26522444
54 MALAT1 bone osteosarcoma up onco RhoA+,ROCK1+,ROCK2 + - + 26575981
55 MALAT1 nervous system glioma up / ERK/MAPk signaling Sox2+,Nestin+ cancer stem cells 26649728
56 MALAT1 breast triple negative breast cancer up onco miR-1- Slug+ + - + - 26676637
57 MALAT1 lung lung cancer / / SNP,chemotherapy resistance 26729200
58 MALAT1 cervix cervical cancer up onco E-cadherin-,ZO-1+,β-catenin+,vimentin+,Snail+ 26798987
59 MALAT1 stomach gastric cancer / onco EZH2,PCDH10- + + - 26871474
60 MALAT1 lung non-small-cell lung cancer up onco CXCL5 + + epigenetic modification 26884862
61 MALAT1 colorectum colorectal cancer / / SRPK1+,SRSF1+,AKAP-9+ 26887056
62 MALAT1 breast breast cancer / / +KDM5B 26917489
63 MALAT1 breast breast cancer up onco miR-124-,CDK4+ + 26918449
64 MALAT1 breast breast cancer / / miR-1 cdc42+ + + 26926567
65 MALAT1 esophagus esophageal squamous cell cancer up onco β-catenin+,Lin28+,OCT4+,E-cadherin- - 27015363
66 MALAT1 nervous system glioma up onco CCND1+,MYC+ + - 27134488
67 MALAT1 breast breast cancer up onco PI3K/AKT pathway Hsa-miR-125b-,YAP- - 27172249
68 MALAT1 gallbladder gallbladder cancer up onco miR-206- ANXA2+,KRAS+,Twist+,vimentin+,E-cadherin- + - + + 27191262
69 MALAT1 breast breast cancer up onco - hormonal resistance 27191888
70 MALAT1 ovary ovarian cancer up onco MMP13+,MMP19-,ADAMTS1- + - + + 27227769
71 MALAT1 ovary ovarian cancer up miR-506- iASPP+ + 28031721
72 MALAT1 breast breast cancer up onco cell cycle genes and EMT maekers + + + - 27250026
73 MALAT1 stomach gastric cancer up onco EGFL7+ + + + 27259812
74 MALAT1 lung lung adenocarcinoma up onco miR-204- E-cadherin-,N-cadherin+,vimentin+,Slug+ + + - 27294002
75 MALAT1 ovary ovarian cancer / onco + - + + 27313681
76 MALAT1 others tongue cancer up onco Wnt/β-catenin β-catenin+,Bax- + - + + + 27353727
77 MALAT1 pancreas pancreatic cancer up onco LC3B-,LC3-,P62-,LAMP-2- - 27371730
78 MALAT1 gallbladder gallbladder cancer up onco miR‐363‐3p- MCL-1+ + - 27420766
79 MALAT1 bone osteosarcoma up onco miR-376A- TGFA+ + 27458156
80 MALAT1 esophagus esophageal cancer up / + + - 27470544

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 200 400 600 800 1000 fpkm 281.0 719.0 879.0 420.0 146.0 375.0 1056.0 48.0 60.0 137.0 96.0 271.0 64.0 116.0 84.0 635.0 MALAT1 

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 10 20 30 40 50 60 70 fpkm MALAT1  type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Ma KX, Wang HJ, Li XR, Li T, Su G, et al. (2015). Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma. Tumour Biol 36(5): 3355-9. link pubmed
[2]. Liang J, Liang L, Ouyang K, Li Z, Yi X (2017). MALAT1 induces tongue cancer cells' EMT and inhibits apoptosis through Wnt/β-catenin signaling pathway. J Oral Pathol Med 46(2): 98-105. link pubmed
[3]. Zhou X, Liu S, Cai G, Kong L, Zhang T, et al. (2015). Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. Sci Rep 5: 15972. link pubmed
[4]. Huang C, Yu Z, Yang H, Lin Y (2016). Increased MALAT1 expression predicts poor prognosis in esophageal cancer patients. Biomed Pharmacother 83: 8-13. link pubmed
[5]. Li J, Wang J, Chen Y, Li S, Jin M, et al. (2016). LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204. Am J Cancer Res 6(5): 1099-107. link pubmed
[6]. Guo F, Jiao F, Song Z, Li S, Liu B, et al. (2015). Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells in vitro. Biochem Biophys Res Commun 465(2): 293-8. link pubmed
[7]. Liu R, Li J, Lai Y, Liao Y, Liu R, et al. (2015). Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1. Int J Biol Macromol 81: 491-7. link pubmed
[8]. Qi Y, Ooi HS, Wu J, Chen J, Zhang X, et al. (2016). MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10. Oncotarget 7(11): 12693-703. link pubmed
[9]. Wang J, Wang H, Zhang Y, Zhen N, Zhang L, et al. (2014). Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer. Cell Signal 26(5): 1048-59. link pubmed
[10]. Cho SF, Chang YC, Chang CS, Lin SF, Liu YC, et al. (2014). MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression. BMC Cancer 14: 809. link pubmed
[11]. Wu XS, Wang XA, Wu WG, Hu YP, Li ML, et al. (2014). MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. Cancer Biol Ther 15(6): 806-14. link pubmed
[12]. Cai X, Liu Y, Yang W, Xia Y, Yang C, et al. (2016). Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma. J Orthop Res 34(6): 932-41. link pubmed
[13]. Liu JH, Chen G, Dang YW, Li CJ, Luo DZ (2014). Expression and prognostic significance of lncRNA MALAT1 in pancreatic cancer tissues. Asian Pac J Cancer Prev 15(7): 2971-7. link pubmed
[14]. Yang MH, Hu ZY, Xu C, Xie LY, Wang XY, et al. (2015). MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9. Biochim Biophys Acta 1852(1): 166-74. link pubmed
[15]. Wang F, Ren S, Chen R, Lu J, Shi X, et al. (2014). Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer. Oncotarget 5(22): 11091-102. link pubmed
[16]. Han Y, Liu Y, Nie L, Gui Y, Cai Z (2013). Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology 81(1): 209.e1-7. link pubmed
[17]. Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, et al. (2015). Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. Cancer Res 75(7): 1322-31. link pubmed
[18]. Yang L, Bai HS, Deng Y, Fan L (2015). High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion. Eur Rev Med Pharmacol Sci 19(17): 3187-93. link pubmed
[19]. Zhou Y, Xu X, Lv H, Wen Q, Li J, et al. (2016). The Long Noncoding RNA MALAT-1 Is Highly Expressed in Ovarian Cancer and Induces Cell Growth and Migration. PLoS One 11(5): e0155250. link pubmed
[20]. Chou J, Wang B, Zheng T, Li X, Zheng L, et al. (2016). MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. Biochem Biophys Res Commun 472(1): 262-9. link pubmed
[21]. Hu L, Wu Y, Tan D, Meng H, Wang K, et al. (2015). Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res 34: 7. link pubmed
[22]. Dong Y, Liang G, Yuan B, Yang C, Gao R, et al. (2015). MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway. Tumour Biol 36(3): 1477-86. link pubmed
[23]. Han Y, Liu Y, Zhang H, Wang T, Diao R, et al. (2013). Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1. FEBS Lett. link pubmed
[24]. Feng T, Shao F, Wu Q, Zhang X, Xu D, et al. (2016). miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation. Oncotarget 7(13): 16205-16. link pubmed
[25]. Wang X, Li M, Wang Z, Han S, Tang X, et al. (2015). Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J Biol Chem 290(7): 3925-35. link pubmed
[26]. Wang SH, Zhang WJ, Wu XC, Zhang MD, Weng MZ, et al. (2016). Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206. Oncotarget 7(25): 37857-37867. link pubmed
[27]. Zhao Z, Chen C, Liu Y, Wu C (2014). 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochem Biophys Res Commun 445(2): 388-93. link pubmed
[28]. Lu H, He Y, Lin L, Qi Z, Ma L, et al. (2016). Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145. Tumour Biol 37(2): 1683-91. link pubmed
[29]. Ji Q, Liu X, Fu X, Zhang L, Sui H, et al. (2013). Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One 8(11): e78700. link pubmed



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