MINCR

Gene basic information

symbol MINCR
name MYC-induced long non-coding RNA
location 8q24.3
alias_symbol TCONS_00015189
alias_name
Tissuebone marrow,gallbladder,
CancerBurkitt lymphoma,gallbladder cancer,


Description

LncRNA MINCR has the highest and most significant positively correlated with MYC expression level. It has the MYC binding regions around its transcriptional start site (TSS) in burkitt lymphoma (BL) cells and P493-6 cells, with increasing peak intensity in MYC high conditions in P493-6 cells. Moreover, MINCR has all of the marks associated with open chromatin and active transcription in normal and malignant B cells. Besides, the expression of MINCR is reduced after MYC knockdown in BL cell lines. Functionally, MINCR knockdown is associated with impairment in cell cycle progression. Differential gene expression analysis after RNAi, shows among the genes down-regulated, a significant enrichment of cell cycle genes after MINCR knockdown. Interestingly, these genes are enriched in MYC binding sites in their promoters, indicating that MINCR acts as a modulator of the MYC transcriptional program. Accordingly, MINCR knockdown is associated with a reduction in MYC binding to the promoters of selected cell cycle genes. Finally, downregulation of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 involve with the reduction in cellular proliferation observed on MINCR knockdown (1).
Besides, MINCR is also up-regulated in gallbladder cancer. It can promote gallbladder cancer cell proliferation and invasion (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 MINCR bone marrow Burkitt lymphoma up onco MYC + 26351698
1 MINCR gallbladder gallbladder cancer up onco EZH2+,E-cadherin-,vimentin+ + + + 27345740

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm 0.8 0.7 2.0 1.0 1.0 0.5 1.0 0.2 0.1 0.6 0.6 1.0 3.0 1.0 0.8 3.0 MINCR

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 fpkm MINCR type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, et al. (2015). MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A 112(38): E5261-70. link pubmed
[2]. Wang SH, Yang Y, Wu XC, Zhang MD, Weng MZ, et al. (2016). Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression. Cancer Lett 380(1): 122-33. link pubmed



© Bioinformatics Group of XTBG