MIR31HG

Gene basic information

symbol MIR31HG
name MIR31 host gene
location 9p21.3
alias_symbol LOC554202|hsa-lnc-31
alias_name
Tissuebladder,breast,colorectum,stomach,
Cancerbladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer,


Description

LncRNA MIR31HG is higher in breast cancer (1), lower in colorectal cancer (2), triple negative reast Cancer (3), bladder cancer (4), and gastric cancer (5). It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 MIR31HG breast triple negative breast cancer down / miR-31+ epigenetic modification 22289355
1 MIR31HG breast breast cancer up onco + - + + 24631686
2 MIR31HG colorectum colorectal cancer down TS + 26362196
3 MIR31HG stomach gastric cancer down TS E2F1-,p21+ - + 26692098
4 MIR31HG bladder bladder cancer down / 27434291

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 fpkm 0.0 0.0 0.5 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.1 0.2 MIR31HG

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 fpkm MIR31HG type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Shi Y, Lu J, Zhou J, Tan X, He Y, et al. (2014). Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. Biochem Biophys Res Commun 446(2): 448-53. link pubmed
[2]. Ding J, Lu B, Wang J, Wang J, Shi Y, et al. (2015). Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades. J Exp Clin Cancer Res 34: 100. link pubmed
[3]. Augoff K, McCue B, Plow EF, Sossey-Alaoui K (2012). miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer 11: 5. link pubmed
[4]. He A, Chen Z, Mei H, Liu Y (2016). Decreased expression of LncRNA MIR31HG in human bladder cancer. Cancer Biomark 17(2): 231-6. link pubmed
[5]. Nie FQ, Ma S, Xie M, Liu YW, De W, et al. (2016). Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer. Tumour Biol 37(6): 7693-701. link pubmed



© Bioinformatics Group of XTBG