Gene basic information

Cancerbreast cancer,hepatic cancer,non-small-cell lung cancer,


LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) (1) and hepatocellular carcinoma (2) and high MVIH expression is correlated with Ki67 expression (3). Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters (3, 1, 2). In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis (3, 2479317, 2). Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9 (1). Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of PGK1, but could not regulate the function of PGK1 in glycolysis (2).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 MVIH liver hepatic cancer up onco PGK1 22706893
1 MVIH lung non-small-cell lung cancer up onco MMP2+,MMP9+ + + - 24793017
2 MVIH breast breast cancer up onco Ki67 + + - 26555546


[1]. Nie FQ, Zhu Q, Xu TP, Zou YF, Xie M, et al. (2014). Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. Tumour Biol 35(8): 7587-94. link pubmed
[2]. Yuan SX, Yang F, Yang Y, Tao QF, Zhang J, et al. (2012). Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology 56(6): 2231-41. link pubmed
[3]. Lei B, Xu SP, Liang XS, Li YW, Zhang JF, et al. (2016). Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer. Tumour Biol 37(4): 5257-64. link pubmed

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