NBAT1

Gene basic information

symbol NBAT1
name neuroblastoma associated transcript 1
location 6p22.3
alias_symbol NBAT-1
alias_name neuroblastoma associated transcript-1
Tissuebreast,kidney,nervous system,
Cancerbreast cancer,neuroblastoma,renal clear cell cancer,


Description

LncRNA NBAT1 is down-regulated in breast cancer and associated with tumor metastasis and poor patient prognosis. NBAT1 can inhibit migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2-dependent manner, and responsible for NBAT1's effects on inhibiting migration and invasion of breast cancer cells (1).
While in neuroblastoma, CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT1 differential expression. Loss of NBAT1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. loss of NBAT1 could affect neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST (2).
Besides, NBAT1 is also down-regulated in renal cell carcinoma and correlated with histological grade, tumor stage, lymph node metastasis, and poor prognosis. NBAT1 promotes cell proliferation, migration and invasion (3).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 NBAT1 nervous system neuroblastoma / TS NRSF/REST pathway EZH2 SOX9-,VCAN- - - - + 25517750
1 NBAT1 kidney renal clear cell cancer down TS - - - + 26097558
2 NBAT1 breast breast cancer down TS EZH2 DKK1+ - - + 26378045

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.000 0.025 0.050 0.075 0.100 0.125 0.150 0.175 0.200 fpkm 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.1 NBAT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 fpkm NBAT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Hu P, Chu J, Wu Y, Sun L, Lv X, et al. (2015). NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2. Oncotarget 6(32): 32410-25. link pubmed
[2]. Pandey GK, Mitra S, Subhash S, Hertwig F, Kanduri M, et al. (2014). The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Cancer Cell 26(5): 722-37. link pubmed
[3]. Xue S, Li QW, Che JP, Guo Y, Yang FQ, et al. (2015). Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma. Int J Clin Exp Pathol 8(4): 3765-74. link pubmed



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