NKILA

Gene basic information

symbol NKILA
name NF-kappaB interacting lncRNA
location 20q13.31
alias_symbol
alias_name
Tissuebreast,
Cancerbreast cancer,


Description

LncRNA NKILA (NF-KappaB Interacting LncRNA) is decreased and associated with breast cancer metastasis and poor patient prognosis. Mechanism studies show that NKILA is up-regulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. NKILA interacts with NF-κB/IκB to form a stable complex. Importantly, NKILA is essential to prevent over-activation of NF-κB pathway in inflammation-stimulated breast epithelial cells (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 NKILA breast breast cancer down TS P65,+NF-κB - + 25759022

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.5 0.6 0.1 0.4 0.8 0.3 0.2 0.2 0.0 0.6 0.3 0.8 1.0 0.2 0.5 0.9 NKILA

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Liu B, Sun L, Liu Q, Gong C, Yao Y, et al. (2015). A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell 27(3): 370-81. link pubmed



© Bioinformatics Group of XTBG