numb

Gene basic information

symbol NUMB
name NUMB, endocytic adaptor protein
location 14q24.3
alias_symbol
alias_name
Tissueothers,
Canceruveal melanoma,


Description

LncRNA-numb is encoded by the LOC101928143 gene, whose locus is in the upstream of the protein-coding gene numb and encodes two different transcripts, 635bp and 644bp in size. qRT-PCR shows that LncRNA-635 is significantly down-regulated in uveal melanoma (UM) cells compared with the control, while the lncRNA-644 transcript did not exist. Moreover, lncRNA- numb is modulated by HIC1 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 numb others uveal melanoma up / +HIC1 27449031

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 fpkm 6.0 8.0 4.0 7.0 8.0 4.0 10.0 22.0 5.0 15.0 9.0 8.0 11.0 3.0 7.0 7.0 numb

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Cheng G, He J, Zhang L, Ge S, Zhang H, et al. (2016). HIC1 modulates uveal melanoma progression by activating lncRNA-numb. Tumour Biol 37(9): 12779-12789. link pubmed



© Bioinformatics Group of XTBG