Gene basic information

symbol NUMB
name NUMB, endocytic adaptor protein
location 14q24.3
Canceruveal melanoma,


LncRNA-numb is encoded by the LOC101928143 gene, whose locus is in the upstream of the protein-coding gene numb and encodes two different transcripts, 635bp and 644bp in size. qRT-PCR shows that LncRNA-635 is significantly down-regulated in uveal melanoma (UM) cells compared with the control, while the lncRNA-644 transcript did not exist. Moreover, lncRNA- numb is modulated by HIC1 (1).

Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 numb others uveal melanoma up / +HIC1 27449031

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 fpkm 6.0 8.0 4.0 7.0 8.0 4.0 10.0 22.0 5.0 15.0 9.0 8.0 11.0 3.0 7.0 7.0 numb

Expression profile in human body map

Genomic feature visualization


External link


[1]. Cheng G, He J, Zhang L, Ge S, Zhang H, et al. (2016). HIC1 modulates uveal melanoma progression by activating lncRNA-numb. Tumour Biol 37(9): 12779-12789. link pubmed

© Bioinformatics Group of XTBG