NUTF2P3-001

Gene basic information

symbol NUTF2P3
name nuclear transport factor 2 pseudogene 3
location 9q21.2
alias_symbol
alias_name
Tissuepancreas,
Cancerpancreatic cancer,


Description

LncRNA NUTF2P3-001 is over-expressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with tumor size, tumor differentiation, TNM stage, lymphatic invasion, distant metastasis and survival time of patients. Knockdown of lncRNA-NUTF2P3-001 inhibits viability, proliferation and invasion in pancreatic cancer cell, accompanying with decreased KRAS expression. Mechanism studies show that NUTF2P3-001 regulates KRAS expression through competitively binding with miR-3923. Moreover, NUTF2P3-001 is transcriptionally up-regulated by HIF-1α in hypoxia (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 NUTF2P3-001 pancreas pancreatic cancer up onco miR-3923 KRAS+,+HIF-1α + + + - 26755660

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 fpkm 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 NUTF2P3-001

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Li X, Deng SJ, Zhu S, Jin Y, Cui SP, et al. (2016). Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway. Oncotarget 7(5): 6000-14. link pubmed



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